Trigonelline bụ alkaloid a na-emekarị nke a na-ahụ na osisi dịka fenugreek na kọfị. Trigonelline HCl, ụdị hydrochloride nke trigonelline, bụ ihe na-adọrọ adọrọ nke na-ekere òkè n'ịkwado ụkpụrụ shuga ọbara, ọrụ lipid nwere ike ime na metabolism na ọrụ ọgụgụ isi. Ka nyocha na-aga n'ihu na ogige a, ọ dị mkpa ka ị na-emelite ihe ọhụrụ. Ma ị nwere mmasị na ọgwụ naturopathic, mmepụta ọgwụ, ma ọ bụ naanị ịchọrọ ịgbasa ihe ọmụma gị, trigonelline HCL bụ isiokwu ị ga-elele na 2024.
Aha sayensị nke trigonelline bụ trimethylxanthine. Ọ bụ ogige alkaline nwere nitrogen ma bụrụ nke pyridine alkaloids. A na-enwetakarị Trigonelline site na osisi fenugreek nke leguminous. Fenugreek bụ ahịhịa ahịhịa. Ọ bụ ahịhịa herbaceous kwa afọ nke sitere na West Africa ma na-ekesa ugbu a na Africa, Europe, Asia na mpaghara ndị ọzọ. Na mgbakwunye, a na-ahụkwa ya na kọfị kọfị, alfalfa, akwụkwọ mulberry, radish, soybean na osisi ndị ọzọ, yana molluscs, azụ mmiri na anụ mammals. Agwa kọfị bụ isi mmalite nke trigonelline mgbe fenugreek gasịrị. Ugbu a, enwere ọtụtụ ụzọ iji tụọ trigonelline na kọfị kọfị, gụnyere chromatography mmiri na-arụ ọrụ dị elu, spectrophotometry, wdg.
Trigonelline bụ ihe mbụ na-emepụta ekpomeekpo n'oge ịsa kọfị. Ọ bụ otu n'ime isi iyi ilu na kọfị. Ọ bụkwa ihe mmalite nke ọtụtụ ogige aromatic. N'oge a, ọ bụ akụrụngwa ọhụrụ nwere ike ịmepụta nri na-arụ ọrụ mgbochi ịka nká.
Trigonelline nwere ọrụ dị iche iche nke anụ ahụ, gụnyere antioxidant, na-ebelata shuga ọbara, na-ekpochapụ radicals n'efu, na-eme ka ọrụ mitochondrial dịkwuo elu, na-abawanye ike anụ ahụ, ibelata mmebi cell, meziwanye ọrụ ọgụgụ isi, wdg dabere na nke a, a na-eji trigonelline eme ihe na nkà mmụta ọgwụ, ihe ịchọ mma, na oriri na-edozi ahụ. Mgbakwunye, ngwaahịa ahụike na mpaghara ndị ọzọ egosila ezigbo atụmanya ngwa. Ka ọ dị ugbu a, a na-ere ahịa trigonelline, mana enwere ngwaahịa azụmahịa ole na ole ma ahịa ahụ nwere ohere sara mbara maka mmepe. Site na nyocha miri emi n'ọdịnihu, a ga-emepụta ngwaahịa ndị ọzọ nwere trigonelline dị ka akụkụ bụ isi n'ọdịnihu.
A na-akpọkarị ụlọ ọrụ ike nke cell, mitochondria na-arụ ọrụ dị mkpa n'ịwepụta ume maka ọrụ cellular. Trigonelline hydrochloride bụ alkaloid sitere n'okike achọtara na osisi dịka fenugreek ma nweta nlebara anya maka mmetụta ọ nwere na ọrụ mitochondrial.
Mitochondria na-ahụ maka imepụta adenosine triphosphate (ATP), isi iyi ike maka usoro cellular. Arụ ọrụ nke mitochondrial nwere ike ibute ọtụtụ nsogbu ahụike, gụnyere ọrịa metabolic, ọrịa neurodegenerative, na ọrịa ndị metụtara ịka nká. Ya mere, ịghọta ihe ndị na-emetụta ọrụ mitochondrial dị oke mkpa na ngalaba nke usoro ihe ọmụmụ cell na ọgwụ.
Mitochondrial dysfunction na belata ọkwa NAD + na-arụ ọrụ dị mkpa na usoro nke mfu ahụ. Mitochondria bụ ebe mmepụta ume n'ime sel, na-ahụ maka imepụta molekul ume ATP nke sel chọrọ. Mgbe arụrụ ọrụ mitochondrial mebiri ma ọ bụ mebie ya, ọ ga-eduga n'inweta ike zuru oke na sel, na-emetụta ọrụ nkịtị na usoro metabolic nke mkpụrụ ndụ akwara, si otú a na-eme ka ọnọdụ nke mfu ahụ dịkwuo elu.
Na mgbakwunye, NAD + (nicotinamide adenine dinucleotide) bụ coenzyme dị mkpa na sel, na-etinye aka na ịhazi metabolism ike na mmeghachi omume redox na sel. Ka anyị na-aka nká, ọkwa NAD + na sel ga-ebelata. Mbelata nke ọkwa NAD + nwere ike imetụta nguzozi redox intracellular, na-eme ka nrụgide oxidative cellular na nzaghachi mkpali dịkwuo njọ, si otú ahụ na-emetụta ọrụ na ndụ nke mkpụrụ ndụ akwara.
Mmetụta nke trigonelline n'ịkwalite ọrụ mitochondrial na-apụtakarị n'akụkụ ndị a:
1. Melite ọrụ mitochondrial
Nnyocha na-egosi na Trigonelline HCl nwere ike ịhazi ọrụ mitochondrial site na-emetụta eriri ụgbọ njem eletrọn, usoro mgbagwoju anya protein na-emepụta ATP. Site n'ịbawanye arụmọrụ nke yinye njem elektrọn, trigonelline HCl nwere ike ịkwalite mmepụta ATP, si otú a na-akwado metabolism ike cell.
Na mgbakwunye, trigonelline nwere ike ịbawanye ọkwa NAD +, yana NAD + bụ isi coenzyme maka phosphorylation oxidative na mitochondria. Site n'ịbawanye ọkwa NAD +, trigonelline nwere ike mee ka agbụ iku ume mitochondrial ma kwalite njikọ ATP, si otú ahụ na-abawanye ọrụ mitochondrial. Nke a na-enyere mkpụrụ ndụ aka ịnọgide na-enwe ike zuru oke maka nzaghachi nrụgide mpụga ma nọgide na-arụ ọrụ cell nkịtị.
2. Chebe mitochondria site na mmebi
Trigonelline nwere mmetụta antioxidant na mgbochi mkpali, nwere ike wepu free radicals na mkpali ihe na mkpụrụ ndụ, na ibelata oxidative nrụgide na mkpali mmebi mitochondria. N'otu oge ahụ, trigonelline nwekwara ike ime ka ọkpụkpụ akpụkpọ ahụ mitochondrial guzosie ike, gbochie mbelata nke mitochondrial akpụkpọ anụ na oghere nke mitochondrial permeability transpores, si otú ahụ na-echebe mitochondria site na mmebi.
3. Kwalite biogenesis mitochondrial
Trigonelline nwere ike kpalite mmegharị na ndegharị nke DNA mitochondrial ma kwalite njikọ nke protein mitochondrial, si otú ahụ na-abawanye ụba na ogo nke mitochondria. Nke a na-enyere mkpụrụ ndụ aka ịbawanye ọnụ ọgụgụ mitochondria ngwa ngwa ma melite arụmọrụ mmepụta ume mgbe ị na-azaghachi mkpa ume.
4. Na-akwalite mmetụta insulin
Nnyocha na-egosi na trigonelline hydrochloride nwere ike imetụta metabolism metabolism na insulin sensitivity, nke nwere njikọ chiri anya na ọrụ mitochondrial. Trigonelline HCl nwere ike na-akwadoghị ahụike mitochondrial na nguzozi ike cellular site n'ịkwalite iji glucose na-arụ ọrụ nke ọma na nrịbama insulin.
Trigonelline, nke a makwaara dị ka N-methylnicotinic acid, bụ alkaloid nke na-emekarị n'ụdị osisi dị iche iche, gụnyere fenugreek, kọfị kọfị, na ihe ọkụkụ ndị ọzọ.
Trigonelline HCl,N'aka nke ọzọ, bụ hydrochloride nnu ụdị trigonelline. Nke a pụtara na trigonelline hydrochloride bụ mpụta nke trigonelline nke ejirila hydrochloric acid mee nnu. Mgbanwe a na-agbanwe nhazi kemịkalụ nke trigonelline, na-ebute ọdịiche dị na njirimara ya na ihe eji eme ya.
Otu n'ime isi ihe dị iche n'etiti trigonelline na trigonelline hydrochloride bụ solubility ha. Trigonelline dị ntakịrị soluble na mmiri, ebe trigonelline hydrochloride na-agbaze karịa na mmiri. Mmụba solubility nke trigonelline hydrochloride na-eme ka ọ dịkwuo mma maka ngwa ụfọdụ, dị ka nhazi nke ihe mgbakwunye nri ma ọ bụ ọgwụ ndị na-achọ mmiri solubility.
N'ihe gbasara uru ahụike nwere ike ime, a mụọla trigonelline na trigonelline HCl maka mmetụta ha na akụkụ dị iche iche nke ahụike. A mụọla Trigonelline maka ọrụ ọ nwere n'ịkwado ụkpụrụ glucose ọbara, metabolism lipid, na ọrụ ọgụgụ isi. Ụfọdụ nnyocha na-atụkwa aro na trigonelline nwere ike ịnwe antioxidant na mgbochi mkpali, nke nwere ike inye aka na mmetụta ya na-akwalite ahụ ike.
N'otu aka ahụ, ụbara solubility nke trigonelline hydrochloride nwere ike ime ka ọ dịkwuo ndụ na anụ ahụ na-etinye ya ngwa ngwa, nwere ike ịkwalite arụmọrụ ya na ngwa ụfọdụ. Nke a dị mkpa karịsịa na mmepe nke ihe mgbakwunye nri ma ọ bụ usoro ọgwụ, ebe trigonelline bioavailability bụ isi nlebara anya.
N'ime ụwa mgbakwunye nri, trigonelline na trigonelline HCl nwere ike ịgụnye dị ka ihe eji eme ihe n'ụdị ezubere iche maka nkwado metabolic, ọrụ ọgụgụ isi, ma ọ bụ ebumnuche metụtara ahụike ndị ọzọ. Mkpebi iji trigonelline ma ọ bụ trigonelline HCl n'ụdị mgbakwunye nwere ike ịdabere na ihe ndị dị ka ụdị usoro onunu ogwu achọrọ, ihe ndị a chọrọ, na uru ahụike akọwapụtara.
Trigonelline HCl bụ nnu hydrochloride nke trigonelline. Nke a pụtara na trigonelline hydrochloride bụ mpụta nke trigonelline nke ejirila hydrochloric acid mee nnu.
N'ihe banyere uru ahụike ya, ụbara solubility nke trigonelline hydrochloride nwere ike ime ka ọ dịkwuo ndụ ma na-etinye ya ngwa ngwa site na ahụ, nwere ike ịkwalite arụmọrụ ya na ngwa ụfọdụ.
1. Mgbochi ịka nká
Isiokwu nke ịka nká mgbe niile na-agbagharị gburugburu otu mkpụrụ ndụ isi-NAD +, nicotinamide adenine dinucleotide. Coenzyme intracellular dị mkpa na-arụ ọrụ dị mkpa n'ịhazi metabolism ike na mmeghachi omume redox. Ọ nwere aha "Youth factor" na "akụ akụ oge ọgaranya".
NAD + bụ isi ihe na-akwado metabolism ike cellular. Ka anyị na-aka nká, ọkwa NAD+ na sel na-ebelata.
Ụfọdụ nnyocha ndị gara aga na-atụ aro na ịgbalị ịbawanye ọkwa NAD + nwere ike iji dị ka atụmatụ iji belata ịka nká. Enwere ọtụtụ ihe na nri na-enyere aka ịbawanye NAD +, dị ka NR (nicotinamide ribose), Trp (tryptophan) na Nam (nicotinamide), yana vitamin B3 (nke a na-akpọ niacin), nke na-eme dị ka NAD + Precursor molecules nwere ike ịmepụta NAD + mgbe ewerechara ya n'ime ahụ.
Nnyocha ọhụrụ na-ekpughe na trigonelline bụkwa ihe NAD + precursor molecule. Trigonelline nwere ike ịbawanye ọkwa NAD + ihe dịka 50% ma e jiri ya tụnyere NMN, nke nwere ike ịbawanye ọkwa NAD + ihe dị ka ugboro abụọ. Otú ọ dị, trigonelline ka nwere ike ịnọgide na-etinye uche dị elu na serum 72 awa mgbe mgbakwunye, ebe NMN na-apụ n'anya ngwa ngwa mgbe agbanwere ya na NAM.
Na-agbakwunye Trigonelline HCl nwere ike ịbawanye ọkwa NAD +, mụbaa ọrụ mitochondrial, ma nyere aka melite usoro ịka nká.
2. Mụbaa ọkwa NAD + ma melite atrophy muscle
Sarcopenia, nke a makwaara dị ka sarcopenia, bụ ọrịa nke mbelata nke anụ ahụ anụ ahụ na oke, nke jikọtara ya na usoro ịka nká ma mara site na mbelata nke ọkpụkpụ skeletal na ike ya. Ngosipụta ụlọ ọgwụ ya na-agụnyekarị ibu ibu, mbelata ike anụ ahụ, ike njide ebelata, mmegharị agbanweghị, wdg. N'ọnọdụ siri ike, nsogbu dị ka ihe isi ike n'iguzo ọtọ, ọdịda dị mfe, mgbaji, na arụ ọrụ moto nwere ike ime.
Mbelata nke anụ ahụ skeletal na njupụta ọkpụkpụ na-eme ka ohere nke mgbaji gbajie mgbe ọ daa, ebe atrophy muscle nwere ike ime ka ọrụ moto na-adịghị mma ma na-emetụta ndụ na ọrụ nkịtị nke onye ọrịa. Ka afọ na-abawanye, mgbe afọ 30 gasịrị, oke anụ ahụ na-ebelata na ọnụego 3% ruo 8% kwa afọ; mgbe afọ 65 gachara, ọnụ ọgụgụ mbelata nke anụ ahụ na-abawanye na 6% ruo 15%. Ụfọdụ ndị mmadụ nwere ike ọbụna na-ata ahụhụ site na sarcopenia, nke na-akpata mbelata nke ike na ọrụ ahụ ike, si otú ahụ na-emetụta mmegharị ahụ. N'ọnọdụ ndị siri ike, ọ nwere ike bute nnwere onwe nke anụ ahụ na nkwarụ.
Enwere ihe omume abụọ dị ịrịba ama na ọnọdụ nke sarcopenia: otu bụ mitochondrial dysfunction na sel, nke nwere ike ịghọta nanị dị ka mmepụta zuru oke nke ụlọ ọrụ mmepụta ihe na-ahụ maka ịmepụta ume na sel anụ ahụ; nke ọzọ bụ nicotinamide adenine dinucleus na sel Mbelata ọkwa nke coenzyme molecule NAD +, nke na-arụ ọrụ dị mkpa na metabolism ike na ozugbo na n'ụzọ na-emetụta ọtụtụ ọrụ cellular.
Ọkwa trigonelline dị ala na ndị ọrịa nwere sarcopenia, yana ka mfu ahụ na-apụta, ọkwa trigonelline serum na-ebelata. A na-ejikọta Trigonelline nke ọma na ike akwara na mmepụta ike mitochondrial na akwara ọkpụkpụ, yana ọkwa serum nke trigonelline na-ejikọta ya na ọkwa NAD + na akwara ọkpụkpụ.
Nnyocha na-egosi na enwere ike ịgbakwunye trigonelline site n'ụzọ atọ: nri nri, njikọ microbial, na nhazi usoro ụzọ metabolic.
1) Nri oriri
Iri nri bara ụba na trigonelline bụ ụzọ kpọmkwem isi abawanye ọkwa trigonelline na ahụ. Dịka ọmụmaatụ, agwa kọfị na mkpụrụ osisi fenugreek bụ osisi mara ọgaranya na trigonelline na okike. Otú ọ dị, ịdabere nanị n'ịba ụba kọfị kọfị iji meziwanye nsogbu ahụike metụtara ịka nká nwere ike ọ gaghị adị mfe dịka e chere.
Na mgbakwunye, ihe mmalite nke trigonelline bụ niacin, yabụ enwere ike ịbawanye ọkwa trigonelline n'ime ahụ n'ụzọ na-edoghị anya site na iri nri bara ụba na niacin ma ọ bụ ịgbakwunye niacin.
2) Ngwakọta microbial
Ndị nchọpụta ahụ chọpụtara na oriri eriri nri na-emetụta ọkwa trigonelline n'ime ahụ, ikekwe n'ihi na trigonelline nwekwara ike ịmepụta site na eriri afọ flora metabolism. Ya mere, site n'ịba ụba oriri nke eriri nri, probiotics na ihe ndị ọzọ, anyị nwere ike ịkwalite gburugburu microbial intestinal ma kwalite uto nke microorganisms na-emepụta trigonelline, si otú ahụ na-abawanye ọkwa nke trigonelline n'ime ahụ. Mana ọ dị mma ịmara na enwere mmekọrịta dị mgbagwoju anya n'etiti nri, microbiota gut na ahụike akwara nke chọrọ nyocha ọzọ iji kọwaa.
3) Usoro nke usoro metabolic
NAPRT enzyme bụ isi enzyme na-agbanwe trigonelline ka ọ bụrụ NAD + precursor. Ya mere, site n'ịbawanye nkwupụta nke NAPRT enzyme, arụmọrụ nke ịtụgharị trigonelline na NAD + precursor nwere ike imeziwanye, si otú ahụ na-abawanye ọkwa nke trigonelline n'ime ahụ. Na mgbakwunye, ọmụmụ egosila na trigonelline metụtara S-adenosylmethionine-based methyltransferase. Ya mere, site n'ịbawanye ọrụ nke ụdị methyltransferase a, enwere ike ịkwalite njikọ nke trigonelline n'ime ahụ.
A mụọkwara ọkwa metabolome serum kynurenine/vitamin B na ndị ọrịa nwere sarcopenia yana njikwa ahụike. Ọ dịghị mgbanwe a hụrụ na ọtụtụ metabolites n'oge sarcopenia. Gụnyere ụdị vitamin B3 nwere ike rụọ ọrụ dị ka ihe mmalite NAD+ nwere ike. Otú ọ dị, ndị ọrịa sarcopenia nwere obere mkpokọta trigonelline na-ekesa. Ọmụmụ ihe ahụ chọpụtakwara na trigonelline na-abawanye ọkwa NAD + cellular.
3. Mbelata shuga ọbara na lipids ọbara
Nnyocha egosiwo na n'ụdị oke ọrịa shuga 2, trigonelline nwere ike ibelata shuga ọbara na ọkwa insulin ma mee ka ntinye uche nke insulin dịkwuo elu. Na mgbakwunye, trigonelline na-abawanye ibu nke pancreas, oke ibu nke pancreas na anụ ahụ, yana ọdịnaya insulin, nke na-egosi na trigonelline nwere ike ibelata ọkwa glucose ọbara site n'ịkwalite mmụgharị mkpụrụ ndụ beta pancreatic na imeziwanye nguzogide insulin.
N'ime oke GK ụdị 2 na-arịa ọrịa shuga, trigonelline belatara ọkwa serum na hepatic triglyceride, mbelata ọrụ ịba ọcha n'anya acid synthase, yana ịba ụba carnitine palmitoyltransferase imeju na ọrụ glucokinase.
Na mgbakwunye, trigonelline HCL nwere ike inye aka mezie ọkwa shuga dị n'ọbara ma melite nghọta insulin. Mmetụta ndị a nwere ike ịba uru nye ndị nwere ọrịa shuga ma ọ bụ ndị nọ n'ihe ize ndụ maka ịmalite ọrịa shuga. Na mgbakwunye, trigonelline HCL nwere ike ịkwado ọkwa cholesterol dị mma, nke dị mkpa maka ahụike obi
4. Njirimara antioxidant
Ụdị oxygen na-emeghachi omume (ROS) bụ isi ihe na-egosi nrụgide oxidative, nke nwere ike iduga mmebi cell na ọnọdụ nke ọrịa dị iche iche. Nnyocha achọpụtala na trigonelline nwere ike ọ bụghị naanị ibelata ọkwa ROS intracellular, kamakwa ibelata ọkwa pancreatic malondialdehyde na nitric oxide. , mụbaa superoxide dismutase, catalase, glutathione na inducible nitric oxide synthase omume.
Nke a pụtara na ọ nwere ike inye aka chebe mkpụrụ ndụ site na mmebi nke nrụgide oxidative na free radicals kpatara. Antioxidants na-arụ ọrụ dị mkpa n'ịkwado ahụike zuru oke ma nwee ike inye aka belata ihe ize ndụ nke ọrịa na-adịghị ala ala. Site n'ịchụpụ radicals efu, trigonelline HCL nwere ike itinye aka na ahụike na ogologo ndụ.
5. Melite ọrụ ọgụgụ isi
Nnyocha na-egosi na trigonelline na-eme ka transcriptomics nke mmụta na mbelata ebe nchekwa na ụdị ịka nká-accelerated mouse pron 8 (SAMP8) site na igbochi cytokines pro-inflammatory na ịbawanye ntọhapụ neurotransmitter. Na mgbakwunye, trigonelline nwere ike ime ka uto synaptik na-arụ ọrụ na sel neuroblastoma SK-N-SH, nke metụtara usoro ya na-eme ka ebe nchekwa dịkwuo mma.
Ịdị ọcha na ịdị mma
Ịdị ọcha na ịdị mma kwesịrị ịbụ ihe kachasị mkpa gị mgbe ị na-ahọrọ mgbakwunye trigonelline HCl. Chọọ ngwaahịa emere n'ime akụrụngwa na-agbaso ụkpụrụ njikwa mma ma nwee asambodo ndị ọzọ nke ịdị ọcha na ike. Tụkwasị na nke a, tụlee ịhọrọ ihe mgbakwunye na-enweghị ihe mgbakwunye artificial, fillers, na allergens iji hụ na ị na-enweta ngwaahịa dị elu.
Usoro onunu ogwu na itinye uche
Usoro onunu ogwu na ntinye nke trigonelline HCl nwere ike ịdị iche n'etiti mgbakwunye. A ghaghị ịtụle mkpa gị na ebumnuche ahụike gị mgbe ị na-ahọrọ usoro ọgwụgwọ kwesịrị ekwesị nke ngwaahịa. Dịka ọmụmaatụ, ọ bụrụ na ịchọrọ ịkwado ọrụ ọgụgụ isi, ị nwere ike ịhọrọ ntinye uche dị elu nke trigonelline HCL, ebe obere dose nwere ike dabara maka nkwado ahụike izugbe. Gakwuru onye ọkachamara ahụike mgbe niile ka ikpebi usoro onunu ogwu maka mkpa gị.
Nghọta na ule
Họrọ mgbakwunye trigonelline HCL sitere na ụlọ ọrụ ama ama nke na-ebute nghọta na nnwale siri ike. Chọọ ụdịdị ndị na-enye ozi zuru ezu gbasara isi mmalite, mmepụta na nnwale nke ngwaahịa ha. Nnwale nke ndị ọzọ maka ịdị ọcha, ike, na mmetọ na-eme ka mmeju na ịdịmma na nchekwa. Tụkwasị na nke a, tụlee ngwaahịa ndị a mụọla ụlọ ọgwụ ma ọ bụ nwee ndekọ ndekọ nke nyocha na ndụmọdụ ndị ahịa dị mma.
Ngwakọta mmekọrịta
Ụfọdụ ihe mgbakwunye trigonelline HCl nwere ike ịnwe ihe ndị ọzọ na-emeju mmetụta ya ma nyekwa uru. Dịka ọmụmaatụ, ị nwere ike ịhụ ngwaahịa na-ejikọta trigonelline HCl na ogige ndị ọzọ eke mara maka nkwado nghọta ha ma ọ bụ ihe na-eme ka metabolism dịkwuo elu. Tụlee ma ị na-ahọrọ ihe mgbakwunye trigonelline HCl kwụ ọtọ ma ọ bụ usoro nwere ihe ndị na-emekọrịta ihe iji lebara ọtụtụ akụkụ nke ahụike na ọdịmma gị anya.
Echiche ahụike nkeonwe
Mgbe ị na-ahọrọ mgbakwunye trigonelline HCl, ọ dị mkpa ịtụle ihe ahụike nkeonwe ma ọ bụ ọnọdụ ahụike dị adị. Ọ bụrụ na ị nwere ọnọdụ ahụike ọ bụla ma ọ bụ na-aṅụ ọgwụ, kpọtụrụ onye ọkachamara ahụike tupu ị gbakwunye mgbakwunye ọhụrụ na usoro gị kwa ụbọchị. Ha nwere ike ịnye ntụzịaka ahaziri iche wee nyere gị aka ikpebi ma trigonelline HCl dabara maka mkpa gị.
Suzhou Myland Pharm & Nutrition Inc. etinyela aka na azụmaahịa mgbakwunye nri na-edozi ahụ kemgbe 1992. Ọ bụ ụlọ ọrụ mbụ na China na-emepụta ma na-ere ahịa mpụta mkpụrụ vine.
Site na ahụmịhe afọ 30 na teknụzụ dị elu na atụmatụ R&D kachasị mma, ụlọ ọrụ ahụ ewepụtala ngwaahịa dị iche iche nke asọmpi wee bụrụ mgbakwunye sayensị ndụ ọhụrụ, njikọta omenala na ụlọ ọrụ nrụpụta.
Na mgbakwunye, Suzhou Myland Pharm & Nutrition Inc. bụkwa onye nrụpụta FDA debanyere aha. Akụrụngwa R&D nke ụlọ ọrụ ahụ, akụrụngwa mmepụta na ngwa nyocha bụ nke ọgbara ọhụrụ yana ọtụtụ ọrụ ma nwee ike imepụta kemịkalụ site na milligrams ruo tọn n'ọ̀tụ̀tụ̀, ma na-agbaso ụkpụrụ ISO 9001 na nkọwapụta GMP.
Q: Gịnị ka a na-eji trigonelline HCl?
A: A na-ejikarị Trigonelline HCl dị ka mgbakwunye nri iji kwado ahụike na ịdị mma n'ozuzu ya. A maara ya maka ikike ya ịkwalite ọkwa shuga dị n'ọbara na-akwado ọrụ metabolic.
Ajụjụ: Kedu otu esi eji trigonelline HCl na mgbakwunye nri?
A: Trigonelline HCl na-agụnyekarị na mgbakwunye nri n'ụdị capsules, mbadamba, ma ọ bụ ntụ ntụ. A na-ejikọta ya na ihe ndị ọzọ na-emepụta ihe ndị na-akwado ahụike nke metabolic, ike ike, na ịdị mma n'ozuzu ya.
Ajụjụ: trigonelline HCl ọ dị mma maka oriri?
A: A na-ewere Trigonelline HCl dị mma,
Disclaimer: Edemede a bụ naanị maka ozi izugbe na e kwesịghị ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla. Ụfọdụ ozi biputere blọọgụ na-abịa site na ịntanetị na ọ bụghị ọkachamara. Webụsaịtị a na-ahụ maka nhazi, nhazi na idezi akụkọ. Ebumnuche nke ibuga ozi ndị ọzọ apụtaghị na ị kwenyere n'echiche ya ma ọ bụ kwado na ọdịnaya ya bụ eziokwu. Gakwuru onye ọkachamara ahụike mgbe niile tupu i jiri mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge nzipu: Ọgọst-12-2024
