Ị nọ na njem ahụike ma na-achọ ihe mgbakwunye iji kwalite ahụike anụ ahụ na nke uche gị? Elepụla anya karịa mgbakwunye 7,8-dihydroxyflavone. 7,8-Dihydroxyflavone bụ flavonoid achọtara na ụfọdụ osisi ma mụọ ya maka uru ahụike nwere ike. Nnyocha na-egosi na 7,8-dihydroxyflavone nwere neuroprotective, mgbochi mkpali, na antioxidant Njirimara, na-eme ka ọ bụrụ ihe mgbakwunye ahụike na-ekwe nkwa. Ọ bụrụ na ị na-achọ ime njem ahụike gị gaa n'ọkwa ọzọ, tụlee itinye mgbakwunye 7,8-dihydroxyflavone n'ime usoro gị kwa ụbọchị.
Yabụ kedu ihe bụ kpọmkwem7,8-dihydroxyflavone? 7,8-DHF bụ flavonoid dị na ụfọdụ osisi na akwụkwọ nri. Achọpụtara ya mgbe ọ na-achọ molecule nke na-eṅomi ọrụ nke ụbụrụ na-enweta neurotrophic factor (BDNF), obere molekul na-eme ka otu onye na-anabata ya na-akpọ tropomyosin-related kinase B (TrkB) n'ihi na peptide na-arụ ọrụ na onye na-anabata ya, nke a na-akpọ ụbụrụ- Ihe na-akpata neurotrophic (BDNF), enweghị ike iji ya n'ihi ụbụrụ na-adịghị mma.
Achọpụtara 7,8-DHF dị ka mimetic dị ike nke BDNF, na-eme otu ihe ahụ na TrkB. Nke a pụtara na 7,8-DHF nwere ike ịmepụta mmetụta yiri nke ahụ na ụbụrụ dị ka BDNF, ma nwee ike ịba uru karịa ọgwụgwọ n'ihi nnabata ya na ikike ịgafe ihe mgbochi ụbụrụ ọbara.
N'ihi ike ya ịkpali ndị na-anabata TrkB, ndị na-anabata TrkB na-arụ ọrụ dị mkpa na uto na nlanarị nke neurons na ụbụrụ. Mgbe ndị na-anabata TrkB na-arụ ọrụ, neurons na-enwekarị uto na nchebe. Ọganihu a na-emetụtakarị dendrites nke neurons, nke na-abanye n'ime synapses iji kwurịta okwu na neuron ndị na-esote, na 7,8-DHF egosiwo ịkwalite uto nke dendrites ndị a n'ime synapses, na-enyere aka iweghachi anụmanụ Nkwurịta okwu n'etiti neurons na ihe nlereanya nke ọgụgụ isi. daa.
Ọtụtụ ọmụmụ na-egosi na 7,8-DHF nwere ike imeziwanye mmụta na ebe nchekwa, gbochie ọrịa neurodegenerative, na ọbụna na-akwado ọnọdụ na mmetụta uche. Nchọpụta ndị a ebutela mmasị na mgbakwunye 7,8-dihydroxyflavone dị ka ihe ndị ọzọ sitere n'okike iji kwado ahụike ụbụrụ.
Ọtụtụ ndị mmadụ na-atụgharị na mgbakwunye 7,8-dihydroxyflavone iji kwado ọrụ ọgụgụ isi ha, karịsịa ka ha na-aka nká ma ọ bụ na-eche ihe ịma aka ndị metụtara ebe nchekwa na itinye uche. Echiche nkeiji ogige ndị sitere n'okike na-akwado ahụike ụbụrụ na-adọrọ mmasị karịsịa maka ndị na-ahọrọ eke, usoro zuru oke maka ahụike.
Otu n'ime usoro izizi nke 7,8-dihydroxyflavone bụ ikike ya ime ka ụzọ akara tropomyosin receptor kinase B (TrkB). TrkB bụ onye na-anabata ihe na-akpata neurotrophic nke ụbụrụ na-enweta neurotrophic (BDNF) ma na-arụ ọrụ dị mkpa na uto, nlanarị, na ọrụ nke neurons na etiti na sistem ụjọ. Ịkwalite nke onye na-anabata TrkB site na 7,8-dihydroxyflavone na-eduga na phosphorylation nke ngalaba intracellular ya, na-ebute usoro nke ihe mgbaàmà nke ala, n'ikpeazụ na-akwalite ndụ neuronal, uto na ọdịiche.
Nnyocha egosiwo na 7,8-dihydroxyflavone na-egosipụta mmetụta neuroprotective n'ọtụtụ ụdị nke ọrịa neurodegenerative, dị ka ọrịa Alzheimer na ọrịa Parkinson. Site n'ịgbalite ụzọ akara TrkB, 7,8-dihydroxyflavone na-eme ka ndụ nke neurons dịkwuo mma, na-echebe ha pụọ na nrụgide oxidative na mbufụt, ma na-akwalite nhazi nke njikọ synapti ọhụrụ, nwere ike ịdalata ma ọ bụ ọbụna gbanwee ọdịda ndị a. ọganihu nke ọrịa.
Na mgbakwunye na mmetụta neuroprotective, 7,8-dihydroxyflavone achọpụtala na ọ nwere mmetụta anxiolytic. A na-eche na mmetụta ndị a na-emezigharị site n'ikike ya iji mee ka mmetụta nke BDNF dị na ụbụrụ dịkwuo elu, si otú ahụ na-eme ka neuronal plasticity na resilience na ihu nke nrụgide na nsogbu ọnọdụ uche. Tụkwasị na nke ahụ, ọmụmụ ihe ọmụmụ egosila na 7,8-dihydroxyflavone nwere ike ịkwalite usoro mmụta na ebe nchekwa, na-ebuli ohere nke iji ya na-agwọ ọrịa nhụsianya metụtara ọnọdụ dị ka mgbaka na nhụjuanya ụbụrụ.
Ihe akaebe ọhụrụ na-egosi na ọ nwekwara ike inwe mmetụta bara uru na anụ ahụ na akụkụ ndị ọzọ. Dịka ọmụmaatụ, 7,8-dihydroxyflavone egosiwo na ọ nwere mgbochi mkpali, ihe antioxidant dị iche iche na ụdị cellular na anụmanụ, na-atụ aro ike ya ịgwọ ọrịa na-adịghị ala ala.
Otu n'ime osisi nwere 7-8 dihydroxyflavonoids bụ Tridax procumbens, nke a na-akpọkarị daisy ma ọ bụ Tridax daisy. Osisi a sitere na ebe okpomọkụ ma ejirila ya mee ihe na ọgwụ Ayurvedic maka ọtụtụ ọgwụ ya. Ndị nchọpụta chọpụtara na Tridax procumbens nwere 7 ruo 8 dihydroxyflavonoids, na-akpali mmasị n'ịchọpụta uru ahụike ya.
Osisi ọzọ nwere 7-8 dihydroxyflavone bụ osisi Godmania aesculifolia, nke sitere na Mexico. A na-eji osisi a eme ihe na nkà mmụta ọgwụ Mexico maka mgbochi mkpali na analgesic Njirimara. Nnyocha na-egosi na Godmania aesculifolia nwere 7-8 dihydroxyflavone, nke kpalitere nchọnchọ n'ihu n'ime usoro ọgwụgwọ ya.
Na mgbakwunye na Tridax procumbens na Godmania aesculifolia, a na-eche na ọtụtụ osisi ndị ọzọ nwere 7-8 dihydroxyflavonoids, ọ bụ ezie na a chọkwuru nyocha iji kwado ọnụnọ ha na osisi ndị a. Ndị a gụnyere fisetin na acacia shrub.
1. Nkwalite Mmata: Otu n'ime uru ndị a maara nke ọma nke ihe mgbakwunye 7,8-dihydroxyflavone bụ ikike ya ịkwalite ọrụ ọgụgụ isi. Nnyocha na-egosi na 7,8-DHF na-enyere aka melite ebe nchekwa, mmụta, na ọrụ ụbụrụ zuru ezu. Site n'ịkwalite uto nke mkpụrụ ndụ ụbụrụ ọhụrụ na ime ka njikọ dị n'etiti neurons dị adị, ihe mgbakwunye 7,8-dihydroxyflavone nwere ike inye aka kwado ahụike ụbụrụ gị na ikike nghọta.
2.Mood Nkwado: Na mgbakwunye na uru ọgụgụ isi, ihe mgbakwunye 7,8-dihydroxyflavone gosipụtara na-enwe mmetụta dị mma na ọnọdụ. Nnyocha na-egosi na 7,8-DHF nwere ike inye aka na-achịkwa ndị na-ahụ maka ụbụrụ na-emetụta ọnọdụ uche na ụbụrụ, dị ka dopamine na serotonin, nke na-arụ ọrụ dị mkpa na nhazi ọnọdụ. Site n'ịkwado ndị neurotransmitters ndị a, mgbakwunye 7,8-dihydroxyflavone nwere ike inye aka melite ọnọdụ na ahụike mmetụta uche.
3. Mmetụta Neuroprotective: 7,8-dihydroxyflavone ihe mgbakwunye achọpụtakwara na ọ nwere ihe ndị na-adịghị mma. Nke a pụtara na ha nwere ike inye aka chebe ụbụrụ na usoro ụjọ site na mmebi nke nrụgide oxidative, mbufụt na usoro ndị ọzọ na-emerụ ahụ. Site n'ịkwado ahụike na ọrụ nke mkpụrụ ndụ ụbụrụ, ihe mgbakwunye 7,8-dihydroxyflavone nwere ike inye aka gbochie ọrịa neurodegenerative na ịda mbà n'obi metụtara afọ.
4. Nkwado Antioxidant: Uru ọzọ dị mkpa nke mgbakwunye 7,8-dihydroxyflavone bụ ihe ndị na-akpata antioxidant ya. Antioxidants bụ ogige ndị na-enyere aka chebe ahụ pụọ na mmebi nke radical free, nke bụ ụmụ irighiri ihe na-emerụ ahụ nke nwere ike inye aka na ọrịa dị iche iche na-adịghị ala ala na ịka nká. Site n'ịchụpụ radicals free na ibelata nrụgide oxidative, 7,8-DHF nwere ike inye aka kwado ahụike na ọdịmma zuru oke.
5.Mmetụta mgbochi mkpali: Mbufụt bụ usoro okike nke na-enyere ahụ aka ịlụso ọrịa ọgụ ma gwọọ mmebi. Otú ọ dị, mbufụt na-adịghị ala ala nwere ike ịkpata nsogbu ahụike dị iche iche, gụnyere ọrịa obi, ọrịa shuga, na ọrịa kansa. Ihe mgbakwunye 7,8-Dihydroxyflavone egosiwo na ha nwere mmetụta mgbochi mkpali, na-enyere aka belata ihe ize ndụ nke mbufụt na-adịghị ala ala na ihe ize ndụ ahụike metụtara ya.
Otu n'ime ihe mbụ ị ga-atụle mgbe ị na-ahọrọ mgbakwunye 7,8-dihydroxyflavone bụ àgwà nke ihe ndị ahụ. Chọọ ihe mgbakwunye nwere 7,8-DHF dị ọcha, dị elu na-enweghị ihe njuju agbakwunyere ma ọ bụ ihe eji arụ ọrụ. Ọ dịkwa mkpa ịtụle isi iyi nke 7,8-DHF gị - chọọ ihe mgbakwunye a nwalere maka ịdị ọcha na ike.
Na mgbakwunye na ịdị mma nke ihe mejupụtara ya, ọ dịkwa mkpa ịtụle usoro onunu ogwu na ụdị mgbakwụnye. 7,8-Dihydroxyflavone dị na capsule na uzuzu, na usoro onunu ogwu nwere ike ịdị iche n'etiti ngwaahịa. Biko tụlee mmasị na mkpa nke gị mgbe ị na-ahọrọ ụdị na usoro ọgwụgwọ kacha mma maka gị. Ọ nwekwara ike inye aka ịkpọtụrụ ọkachamara nlekọta ahụike iji chọpụta usoro onunu ogwu nke dabara na mkpa gị.
Ihe ọzọ dị mkpa ị ga-atụle mgbe ị na-ahọrọ mgbakwunye 7,8-dihydroxyflavone bụ aha onye nrụpụta. Chọọ maka mgbakwunye nke ụlọ ọrụ a ma ama mere nke nwere akụkọ ihe mere eme nke imepụta ngwaahịa dị elu, nke a pụrụ ịdabere na ya. Lelee maka asambodo dị ka Ezi Nrụpụta Omume (GMP) na nnwale ndị ọzọ iji hụ na mgbakwunye gị ruru ogo dị elu yana ụkpụrụ nchekwa.
Ọ dịkwa mma ịgụ nyocha na akaebe sitere n'aka ndị ọrụ ndị ọzọ iji nweta echiche nke ịdị irè na ịdị mma nke mgbakwunye. Chọọ nzaghachi sitere n'aka ndị ji ngwaahịa a maka nkwado cognitive na ahụike ụbụrụ zuru oke iji ghọta nke ọma ka mgbakwunye a si arụ ọrụ maka gị.
N'ikpeazụ, tụlee ego na uru nke mgbakwunye gị. Ọ bụ ezie na ọ dị mkpa ịhọrọ ngwaahịa dị elu, ọ dịkwa mkpa ịtụle ọnụ ahịa na uru nke mgbakwunye gị. Tulee ọnụ ahịa ma tụlee ọnụ ahịa ọ na-eri kwa ije ozi iji hụ na ị na-enweta uru ego gị.
Ụlọ ọrụ Suzhou Myland Pharm & Nutrition Inc. etinyela aka na azụmaahịa mgbakwunye nri na-edozi ahụ kemgbe 1992. Ọ bụ ụlọ ọrụ mbụ na China na-emepụta ma na-ere ahịa mịpụta mkpụrụ vine.
Site na ahụmịhe afọ 30 na teknụzụ dị elu na atụmatụ R&D kachasị mma, ụlọ ọrụ ahụ ewepụtala ngwaahịa dị iche iche nke asọmpi wee bụrụ mgbakwunye sayensị ndụ ọhụrụ, njikọta omenala na ụlọ ọrụ nrụpụta.
Na mgbakwunye, ụlọ ọrụ ahụ bụkwa onye nrụpụta ndebanye aha FDA, na-eme ka ahụike mmadụ nwee ogo kwụsiri ike na uto na-adịgide adịgide. Akụrụngwa R&D nke ụlọ ọrụ na akụrụngwa mmepụta yana ngwa nyocha bụ nke ọgbara ọhụrụ yana ọtụtụ ọrụ, ma nwee ike imepụta kemịkalụ na milligram ruo ton n'usoro kwekọrọ n'ụkpụrụ ISO 9001 na usoro nrụpụta GMP.
Q: Gịnị bụ 7,8-Dihydroxyflavone?
A: 7,8-Dihydroxyflavone bụ flavonoid sitere n'okike nke a mụọla maka uru ịdị mma ya nwere ike, gụnyere mmetụta ya na ọrụ ọgụgụ isi na ọdịmma zuru oke.
Ajụjụ: Kedu ka mgbakwunye 7,8-Dihydroxyflavone si arụ ọrụ?
A: A kwenyere na mgbakwunye 7,8-Dihydroxyflavone na-arụ ọrụ site n'ịkwado ọrụ nke protein dị na ụbụrụ a na-akpọ TrkB, nke na-etinye aka na uto na nlanarị nke neurons. Nkwado a nwere ike itinye aka n'ịrụ ọrụ ọgụgụ isi na ịdị mma nke uche.
Ajụjụ: Gịnị bụ uru dị n'iji ihe mgbakwunye 7,8-Dihydroxyflavone?
A: Ụfọdụ uru nwere ike ịnweta ihe mgbakwunye 7,8-Dihydroxyflavone nwere ike ịgụnye nkwalite nchekwa na ọrụ ọgụgụ isi, nkwado maka ahụike ụbụrụ n'ozuzu ya, na mmetụta ndị nwere ike ịkwalite ọnọdụ uche.
Ajụjụ: Kedu ka esi ewere mgbakwunye 7,8-Dihydroxyflavone?
A: Ngwọta kwesịrị ekwesị nke mgbakwunye 7,8-Dihydroxyflavone nwere ike ịdịgasị iche dabere na ihe onye ọ bụla, yabụ ọ kacha mma ịgbaso usoro ọgwụgwọ akwadoro na akara ngwaahịa ma ọ bụ kpọtụrụ onye ọkachamara ahụike maka nduzi.
Disclaimer: Edemede a bụ naanị maka ozi izugbe na e kwesịghị ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla. Ụfọdụ ozi biputere blọọgụ na-abịa site na ịntanetị na ọ bụghị ọkachamara. Webụsaịtị a na-ahụ maka nhazi, nhazi na idezi akụkọ. Ebumnuche nke ibuga ozi ndị ọzọ apụtaghị na ị kwenyere n'echiche ya ma ọ bụ kwado na ọdịnaya ya bụ eziokwu. Gakwuru onye ọkachamara ahụike mgbe niile tupu i jiri mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge nzipu: Feb-20-2024
