Mgbe ị na-ahọrọ N-acetyl-L-cysteine ethyl ester powder emeputa, ọ dị mkpa ịtụle ọtụtụ ihe iji hụ na ị na-enweta ngwaahịa dị elu. N'okpuru ebe a bụ ụfọdụ isi ihe ị ga-atụle mgbe ị na-ahọrọ ndị na-emepụta N-acetyl-L-cysteine ethyl ester powders gụnyere nkwenye dị mma, ikike R & D, ikike mmepụta ihe, wdg Site n'ịtụle ihe ndị a kachasị mkpa, ị nwere ike ime mkpebi nke ọma ma họrọ onye nrụpụta. nke na-egbo mkpa gị na njirisi gị.
NACET bụ ewepụtara N-acetyl-L-cysteine (NAC),ụdị ethyl ester ọhụrụ nke N-acetyl-L-cysteine (NAC), nke a ma ama na nke a na-amụ nke ọma, nke a na-ejikarị eme ihe maka njirimara antioxidant ya na uru ahụike nwere ike. N'ime ha, NACET bụ ụdị NAC gbanwere, yana otu ethyl ester jikọtara na molekul. A na-eche na mgbanwe a ga-eme ka bioavailability na nkwụsi ike nke ogige ahụ, nwere ike imeziwanye ike na vivo.
Ihe na-ekewa NACET iche bụ bioavailability ya dị elu, nke ji okpukpu 20 karịa glutathione ọkọlọtọ na mgbakwunye NAC. Nke a pụtara na mgbe ị na-ewere NACET, ahụ gị na-eji ya eme ihe nke ọma.
Bioavailability a kwalitere na-atụgharị gaa na mmetụta antioxidant dị irè karị, ọkachasị n'ịbawanye ọkwa nke glutathione antioxidant (GSH). NACET nwere ike inye aka kwado ọrụ imeju site n'ịkwalite mmepụta nke glutathione, nke a maara Thione dị ka antioxidant kachasị ike nke anụ ahụ ma na-ekere òkè dị mkpa na imeju imeju.
Na mgbakwunye, NACET nwere ike inye aka chebe mkpụrụ ndụ na anụ ahụ pụọ na mmebi nke nrụgide oxidative kpatara. Ọ bụghị naanị na ọ na-enyere aka ichebe ụbụrụ pụọ na mmebi nke radical free, ọ na-akwadokwa ọrụ ọgụgụ isi, na-eme ka ọ bụrụ ihe jikọrọ aka zuru oke maka ahụike ụbụrụ ogologo oge.
Ọrụ ya na ahụike ahụike enweghị ike ikwubiga ya ókè, na-enyere aka mee ka usoro ahụ ji alụso ọrịa ọgụ sie ike ma na-enye nchebe pụọ na nsogbu ahụike dị iche iche. Okwesiri ikwuputa na NACET gosikwara nkwa n'ịkwado ahụike iku ume. Dị ka ihe na-ebute glutathione, NACET nwere ike inye aka dị nro ma belata mbufụt nke ikuku, yabụ ma ịchọrọ ịkwalite cognition, chebe ahụ pụọ na mmebi oxidative ma ọ bụ ịkwado usoro ahụ ji alụso ọrịa ọgụ, NACET bụ nhọrọ mbụ.
Ọ bụghị naanị mgbakwunye mana ngwa ọrụ dị ike na usoro ahụike gị.
uru:
● Kwalite ọrụ ọgụgụ isi na ahụike ụbụrụ ka mma
●Ọrịa bioavailability dị elu tụnyere ọkọlọtọ NAC na mgbakwunye glutathione
● Kwalite mmetụta mgbochi ịka nká nke mmepụta glutathione
●Mmetụta Neuroprotective nke na-echebe ụbụrụ site na nrụgide oxidative
Mechanism
Tụgharịrị gaa na N-Acetyl Cysteine (NAC): Ozugbo etinyere ya, NACET na-abanye n'ọbara. N'ihi otu ethyl ester, ọ na-enwekwu lipophilic (abụba-soluble) na enwere ike itinye ya nke ọma site na akpụkpọ anụ lipid nke sel. N'ime ahụ, a na-atụgharị NACET ka ọ bụrụ N-acetylcysteine (NAC).
NAC bụ ihe mmalite nke glutathione, otu n'ime antioxidants kachasị mkpa nke ahụ. Glutathione na-arụ ọrụ dị mkpa n'iwepụ radicals efu, na-ebelata nrụgide oxidative na ịkwado usoro imeju imeju. Site n'ịbawanye ọkwa glutathione, NACET na-enyere aka chebe mkpụrụ ndụ site na mmebi oxidative, nke dị mkpa maka ịnọgide na-enwe ahụ ike cell na igbochi mmebi metụtara afọ.
Na mgbakwunye, NAC n'onwe ya nwere akụrụngwa antioxidant. Ọ na-ekpochapụ radicals n'efu, si otú a na-enye aka na nchebe ya megide nrụgide oxidative.
Site na ịtụgharị na NAC, NACET nwere ike imetụta ọkwa glutamate na ụbụrụ. Glutamate bụ neurotransmitter dị mkpa na-etinye aka na mmụta na ebe nchekwa. Ọ nwekwara ihe mgbochi mkpali. E gosiputara NAC ka ọ na-achịkwa mmepụta nke ụfọdụ cytokines, bụ ndị na-egosi ụmụ irighiri ihe na-edozi ma na-achịkwa mgbochi, mbufụt, na hematopoiesis.
NAC, ụdị arụ ọrụ ewepụtara na NACET, na-arụ ọrụ dị ka onye na-ahụ maka mucolytic site na imebi agbụ disulfide na imi, na-eme ka ọ dị ntakịrị viscous na mfe ịchụpụ. Ihe onwunwe a bara uru karịsịa n'ọnọdụ ndị dị ka ọrịa na-adịghị ala ala obstructive pulmonary (COPD) na bronchitis.
1. kwalite mmepụta glutathione
NACET na-akwalite mmepụta nke glutathione, isi antioxidant na ụbụrụ. Nke a na-enyere aka belata nrụgide oxidative na mmebi nke neuronal, nke dị oke mkpa maka ịnọgide na-enwe ahụike uche.
2. Njirimara neuroprotective
Mmetụta antioxidant nke NACET na-enye neuroprotection, nke bara uru n'igbochi ịda mbà n'obi metụtara afọ na ichebe neurotoxins gburugburu ebe obibi. Site n'ịbawanye ọkwa antioxidant, NACET na-echebe mkpụrụ ndụ ụbụrụ site na nrụgide oxidative, nke nwere ike imebi ọrụ ọgụgụ isi ma bute ọrịa neurodegenerative.
3. Melite ahụike uche
Egosiputara NACET nwere uru ahụike uche ma nwee ike inye aka jikwaa ọnọdụ dị ka ịda mbà n'obi na nchekasị n'ihi mmetụta ya na nhazi neurotransmitter.
4. Nkwado cognition ọrụ
Site n'ichekwa neurons na imezi ndị neurotransmitters, NACET nwere ike inye aka chebe ụbụrụ pụọ na nrụgide oxidative ma kwado ahụike ụbụrụ n'ozuzu ya. Nke a na-akwado ọrụ ọgụgụ isi n'ozuzu ya, gụnyere ebe nchekwa, itinye uche, na nghọta nke uche. Na mgbakwunye, NACET na-emetụta neurotransmitters dị ka glutamate, nke na-arụ ọrụ dị mkpa na mmụta na ebe nchekwa. Ọkwa glutamate kwesịrị ekwesị dị mkpa maka ịrụ ọrụ ụbụrụ nkịtị.
5. Na-abawanye ọkwa antioxidant
NACET na-arụ ọrụ nke ọma n'ịbawanye mmepụta ahụ nke glutathione, bụ antioxidant siri ike. Antioxidants na-ekere òkè dị mkpa n'iwepụ radicals na-emerụ ahụ n'ime ahụ, nke nwere ike ịkpata nrụgide oxidative na mmebi cell. Site n'iwepụ radicals n'efu, NACET na-enyere aka ichebe mkpụrụ ndụ site na mmebi oxidative ma na-akwado ahụike cellular n'ozuzu ya. Njirimara antioxidant nke NACET na-eritekwa uru ahụike anụ ahụ, na-enyere aka igbochi mmebi radical n'efu yana nwere ike ibelata ihe ịrịba ama nke ịka nká.
6. Kwalite ọrụ mgbochi
E gosiputara NACET ka ọ na-emegharị usoro ahụ ji alụso ọrịa ọgụ, nwee ike ịkwalite ọrụ mgbochi yana ịkwado ahụike ahụike zuru oke. Site n'ịkwalite mmepụta nke glutathione, NACET nwere ike inye aka ịhazi nzaghachi mgbochi ahụ ma kwado nchebe ahụ megide nje na ndị na-awakpo mba ọzọ.
7. Nkwado imeju
Imeju bụ akụkụ dị mkpa maka detoxification na metabolism. E gosipụtara NACET iji kwado ọrụ imeju site n'ịkwalite mmepụta nke glutathione, antioxidant dị ike nke na-arụ ọrụ dị mkpa na usoro nsị. Site n'ịbawanye ọkwa glutathione, NACET nwere ike inye aka chebe imeju site na mmebi oxidative ma kwado ahụike na ọrụ ya n'ozuzu ya.
A na-amụ NAC n'ụdị ọdịnala ya nke ọma ma jiri ya mee ihe maka akụrụngwa antioxidant ya na ikike ịkwado ahụike imeju, ahụike iku ume na ahụike uche. A na-ejikarị ya eme ihe dị ka ihe mgbakwunye iji kwado usoro nsị nke anụ ahụ ma kwalite ahụike zuru oke.
NACET,N'aka nke ọzọ, bụ ụdị NAC ọhụrụ ewepụtara iji nwee ike ịkwalite bioavailability na ịdị irè nke NAC. Ekwenyere na ụdị ethyl ester ga-enwe nnabata na nkwụsi ike ka mma, nke nwere ike ibute ọkwa NAC dị elu na ahụ yana mmetụta ọgwụgwọ ka mma.
Otu n'ime ọdịiche dị n'etiti NAC na NACET bụ usoro kemịkalụ ha. NAC bụ ụdị acetylated nke amino acid L-cysteine , ebe NACET bụ ụdị NAC gbanwere yana otu ethyl ester. A na-eche na mgbanwe a ga-eme ka ikike ngwakọta ahụ nwee ike ịbanye n'ime membranes cell wee rute anụ ahụ ezubere iche nke ọma.
N'ihe gbasara uru, ụdị abụọ nke NAC nwere ihe ndị yiri ya, dị ka antioxidant na mgbochi mkpali. Agbanyeghị, ụfọdụ ọmụmụ na-egosi na NAC ethyl ester nwere ike ịnwe bioavailability dị elu yana nnabata ekwentị ma e jiri ya tụnyere NAC ọdịnala. Nke a nwere ike ịtụgharị gaa n'ịrụ ọrụ ọgwụgwọ yana obere doses achọrọ iji nweta otu mmetụta ahụ.
1. Ogo ngwaahịa na ịdị ọcha
Ogo na ịdị ọcha nke N-Acetyl-L-Cysteine ethyl Ester ntụ ntụ dị oke egwu. Chọọ ndị na-emepụta ihe na-agbaso usoro njikwa mma siri ike ma nwee asambodo dịka GMP (Good Manufacturing Practices) na ISO (International Organisation for Standardization). Asambodo ndị a na-ahụ na a na-emepụta ngwaahịa na ụlọ ọrụ na-agbaso ụkpụrụ dị elu ma na-agbaso ụkpụrụ mmepụta ihe siri ike.
Na mgbakwunye, jụọ maka isi mmalite akụrụngwa na usoro nrụpụta. Ndị na-emepụta ihe a ma ama ga-apụta ìhè banyere mmalite nke ihe ha na-emepụta na ụzọ ndị e ji emepụta N-acetyl-L-cysteine ethyl ester ntụ ntụ. Ọ dị mkpa ịhọrọ onye nrụpụta nke na-ebute ịdị ọcha na ike ngwaahịa ụzọ.
2. Nnyocha na ike mmepe
Ndị na-emepụta ihe nwere ikike R & D siri ike nwere ike ịmepụta N-acetyl-L-cysteine dị elu ethyl ester ntụ ntụ. Chọọ ndị na-ebubata ihe ndị na-etinye ego na nyocha na ihe ọhụrụ iji kwalite nrụpụta na bioavailability nke ngwaahịa ha. Ndị na-emepụta ihe na-eduzi ọmụmụ ihe na nyocha ụlọ ọgwụ iji kwado uru nke N-acetyl-L-cysteine ethyl ester ntụ ntụ na-egosipụta ntinye aka n'ịmepụta ngwaahịa dị mma.
3. Nrube isi na asambodo
Gbaa mbọ hụ na ndị nrụpụta na-agbaso ụkpụrụ niile dị mkpa ma jide asambodo achọrọ iji mepụta mgbakwunye nri. Nke a gụnyere ịgbaso ụkpụrụ FDA (Nri na Ọgwụ) yana nweta asambodo dịka NSF (National Sanitation Foundation) na USP (United States Pharmacopeia). Asambodo ndị a na-egosi na ndị nrụpụta na-agbaso ụkpụrụ nchekwa siri ike, ịdị mma na ịdị ọcha.
4. Usoro ahaziri ahaziri na nhọrọ akara aha nzuzo
Ọ bụrụ na ị na-achọ ịmepụta usoro pụrụ iche ma ọ bụ nye akara nzuzo maka N-acetyl-L-cysteine ethyl ester ntụ ntụ, tụlee onye nrụpụta na-enye ọrụ nhazi omenala. Nke a na-enye gị ohere ịhazi ngwaahịa gị iji mezuo ihe achọrọ ma kewaa ya na ndị asọmpi gị. Na mgbakwunye, nhọrọ akara nkeonwe na-enyere gị aka ịhazi ngwaahịa gị maka ndị ahịa gị site n'ịkpọ ha akara na nkwakọ ngwaahịa gị.
5. Agbụ ọkọnọ na ikike mmepụta
Nyochaa ụdọ ọkọnọ nke ndị nrụpụta na ikike mmepụta iji hụ na ntinye ntụ ntụ N-acetyl-L-cysteine ester na-agbanwe agbanwe. Agbụ ọkọnọ siri ike na ikike nrụpụta zuru oke dị oke mkpa iji gboo mkpa na izere ụkọ nwere ike. Jụọ maka oge ndu nke onye nrụpụta, njikwa ngwa ahịa, yana ike iwepụta mmepụta iji nabata uto azụmaahịa.
Myland Pharm & Nutrition Inc. etinyela aka na azụmaahịa mgbakwunye nri na-edozi ahụ kemgbe 1992. Ọ bụ ụlọ ọrụ mbụ na China na-emepụta ma na-ere ahịa mịpụta mkpụrụ vine.
Site na ahụmịhe afọ 30 na teknụzụ dị elu na atụmatụ R&D kachasị mma, ụlọ ọrụ ahụ ewepụtala ngwaahịa dị iche iche nke asọmpi wee bụrụ mgbakwunye sayensị ndụ ọhụrụ, njikọta omenala na ụlọ ọrụ nrụpụta.
Na mgbakwunye, Myland Pharm & Nutrition Inc. bụkwa onye nrụpụta FDA debanyere aha. Akụrụngwa R&D nke ụlọ ọrụ ahụ, akụrụngwa nrụpụta na ngwa nyocha bụ nke ọgbara ọhụrụ yana ọtụtụ ọrụ, ma nwee ike imepụta kemịkalụ site na milligrams ruo tọn n'ọ̀tụ̀tụ̀, ma na-agbaso ụkpụrụ ISO 9001 na nkọwapụta GMP. .
Ajụjụ: Gịnị bụ isi ihe ị ga-atụle mgbe ị na-ahọrọ N-Acetyl-L-cysteine Ethyl Ester powder emeputa?
A: Ihe kachasị elu gụnyere aha onye nrụpụta, njikwa njikwa mma, ikike mmepụta, nnabata iwu, na ọnụahịa.
Ajụjụ: Kedu ka aha onye nrụpụta si emetụta usoro nhọrọ maka N-Acetyl-L-cysteine Ethyl Ester ntụ ntụ?
A: Aha onye na-emepụta ihe na-egosipụta ntụkwasị obi ya, àgwà ngwaahịa, na afọ ojuju ndị ahịa, na-eme ka ọ bụrụ ihe dị mkpa na usoro nhọrọ.
Ajụjụ: Kedu usoro njikwa mma kwesịrị ịtụle mgbe ị na-ahọrọ N-Acetyl-L-cysteine Ethyl Ester powder emeputa?
A: Usoro njikwa ogo dị ka nrube isi na Omume nrụpụta dị mma (GMP), ụkpụrụ nnwale ngwaahịa, na asambodo dị mkpa iji hụ na ịdị ọcha na nchekwa ngwaahịa.
Ajụjụ: Gịnị kpatara ikike mmepụta ji bụrụ ihe dị mkpa n'ịhọrọ onye nrụpụta N-Acetyl-L-cysteine Ethyl Ester ntụ ntụ?
A: Ikike mmepụta na-ekpebi ikike nke onye nrụpụta iji gboo mkpa nke N-Acetyl-L-cysteine Ethyl Ester ntụ ntụ, na-eme ka ọ bụrụ ihe kwụsiri ike ma na-agbanwe agbanwe.
Disclaimer: Edemede a bụ naanị maka ozi izugbe na e kwesịghị ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla. Ụfọdụ ozi biputere blọọgụ na-abịa site na ịntanetị na ọ bụghị ọkachamara. Webụsaịtị a na-ahụ maka nhazi, nhazi na idezi akụkọ. Ebumnuche nke ibuga ozi ndị ọzọ apụtaghị na ị kwenyere n'echiche ya ma ọ bụ kwado na ọdịnaya ya bụ eziokwu. Gakwuru onye ọkachamara ahụike mgbe niile tupu i jiri mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge nzipu: Eprel-24-2024
