Palmitoylethanolamide bụ endogenous fatty acid amide bụ nke klaasị nke agonists ihe na-akpata nuklia. Ọ bụ otu n'ime ihe kachasị mkpa endogenous analgesic na mgbochi mkpali ogige nke egosiri na ọ dị irè ọ bụghị nanị na nnukwu ma na-adịghị ala ala mgbu. Dị ka ihe na-eme ka mgbu na-egbuke egbuke, ọ bụ ezigbo ihe ọzọ na ọgwụ ọdịnala nke nwere ike ịkpata mmetụta.
Egosiputara PEA ka o nwere ihe mgbochi mkpali, antinociceptive, neuroprotective, na anticonvulsant Njirimara. PEA anọwo na-enyocha ndị nwere ọnọdụ mgbu dị iche iche, mbufụt na ọrịa mgbu na ule ụlọ ọgwụ dị iche iche. Ngwa: Palmitoylethanolamide bụ ihe nkwekọ nke organic na etiti ọgwụ, nke enwere ike iji na nyocha ụlọ nyocha na usoro mmepe yana nyocha kemịkalụ na ọgwụ na usoro mmepe.
N'ime nyocha sayensị taa na mpaghara mmepụta ihe, Palmitoylethanolamide, dị ka akụrụngwa akụrụngwa dị mkpa, enwetala nlebara anya zuru oke maka akụrụngwa kemịkalụ ya pụrụ iche yana atụmanya ngwa sara mbara.
1. Nkwadebe nke Palmitoylethanolamide
Nkwadebe nke Palmitoylethanolamide na-agụnyekarị mmeghachi omume esterification. N'oge usoro nkwadebe, palmitadecanoic acid na ethanol na-enweta mmeghachi omume esterification n'okpuru ọrụ nke ihe na-eme ka ịmepụta palmitadecanamide ethanol. N'oge usoro nkwadebe, ihe ndị dị ka okpomọkụ mmeghachi omume, ụdị ihe na-akpata na usoro onunu ogwu, na oge mmeghachi omume nwere mmetụta dị mkpa na àgwà na mkpụrụ nke ngwaahịa. Ya mere, ịkwalite usoro nkwadebe bụ isi ihe iji melite ogo ngwaahịa na ibelata ọnụ ahịa.
2. Njirimara nke Palmitoylethanolamide
Palmitoylethanolamide bụ ọcha ruo ntakịrị odo siri ike nwere ezigbo solubility na nkwụsi ike. Ọ siri ike na ụlọ okpomọkụ, ma soluble na a dịgasị iche iche nke organic solvents na a ụfọdụ okpomọkụ, dị ka ethanol, acetone, wdg Ke adianade do, Palmitoylethanolamide nwekwara ezi thermal na kemịkal kwụsie ike, nke na-enye ya ohere ịnọgide na-enwe ya Ọdịdị na Njirimara n'okpuru. elu okpomọkụ na mgbagwoju gburugburu.
3. Ngwa nke Palmitoylethanolamide
1. Nchọpụta na mmepe nke ọgwụ na ụlọ nyocha:
●PEA bụ ihe dị mkpa na-emepụta ọgwụ na-emepụta ọgwụ, nke a na-eji na nyocha ụlọ nyocha na usoro mmepe na nyocha ọgwụ ọgwụ na usoro mmepe.
●Egosikwara na ọ nwere mgbochi mkpali, analgesic, neuroprotective na anticonvulsant Njirimara na adabara ọgwụgwọ nke na-adịghị ala ala mgbu, Akwụkwụ na-adọ, cerebral ischemia na ọrịa strok.
2. Ụlọ ọrụ ịchọ mma:
●PEA nwere ọrụ nke surfactant na foam accelerator na-eji na-emepụta ihe ịchọ mma dị ka moisturizers na shampoos.
●Ọ nwere ike ime ka nkwụsi ike na nkwụsi ike nke ngwaahịa ahụ dịkwuo mma, ebe ọ na-eme ka ọ dị mma na-eme ka ọ dịkwuo mma.
3. Ụlọ ọrụ akwa:
A na-eji PEA mee ihe dị ka onye na-eme ka ọ dị nro, onye na-ahụ maka antistatic na mmanu mmanu iji meziwanye nro na gloss nke akwa akwa ma belata ọnụọgụ esemokwu na mmetụta electrostatic.
4. Ụlọ ọrụ plastik:
●Dịka plasticizer, mmanu na dispersant, PEA mma nro na siri ike nke plastics na-ebelata nhazi okpomọkụ na ike oriri.
5. mgbochi mkpali na analgesic:
●PEA na-ebelata ihe mgbaàmà na-egbuke egbuke site n'ịgbanwe mkpụrụ ndụ ihe nketa, nwere mmetụta mgbochi mkpali na analgesic, ma dị mma maka ịgwọ ọnọdụ mgbu dị iche iche na ọrịa ndị na-egbuke egbuke.
6. Ngwa ndị ọzọ nwere ike:
●N'ihe gbasara ike ọhụrụ, PEA nwere ike iji mepụta ihe ike ọhụrụ dị ka mkpụrụ ndụ anyanwụ na batrị lithium-ion.
●N'ihe gbasara nchekwa gburugburu ebe obibi, enwere ike iji ya mepụta plastik biodegradable, mkpuchi gburugburu ebe obibi na ngwaahịa ndị ọzọ na-emetụta gburugburu ebe obibi.
●N'ebe a na-emepụta ọgwụ, a pụrụ iji ya na-emepụta ihe ndị na-emepụta ọgwụ dị ka ndị na-ebu ọgwụ na ihe ndị na-ahapụ ya.
Ojiji ndị a na-egosipụta nnukwu ngwa yana uru palmitamide ethanol nwere n'ọtụtụ ụlọ ọrụ.
4. Ọdịnihu mmepe mmepe nke Palmitoylethanolamide
Site na ọganihu sayensị na teknụzụ na-aga n'ihu na mmepe ngwa ngwa nke ụlọ ọrụ, mpaghara ngwa nke Palmitoylethanolamide ga-aga n'ihu na-agbasawanye. N'ọdịnihu, ntinye nke Palmitoylethanolamide na ike ọhụrụ, nchebe gburugburu ebe obibi, ọgwụ na mpaghara ndị ọzọ ga-eji nwayọọ nwayọọ na-abawanye. Dịka ọmụmaatụ, n'ọhịa nke ume ọhụrụ, Palmitoylethanolamide nwere ike iji mee ihe ike ọhụrụ dị ka mkpụrụ ndụ anyanwụ na batrị lithium-ion; n'ihe gbasara nchekwa gburugburu ebe obibi, enwere ike iji ya mee ihe na-eme ka ihe ndị dị na gburugburu ebe obibi dị ka plastik biodegradable na mkpuchi gburugburu ebe obibi; na ngalaba ọgwụ, enwere ike iji ya rụpụta ihe ndị na-emepụta ọgwụ dịka ndị na-ebu ọgwụ na ndị na-ahapụ ya.
Na mgbakwunye, ka mmata ndị mmadụ banyere ahụike na nchekwa gburugburu ebe obibi na-aga n'ihu, ịdịmma na arụmọrụ chọrọ maka Palmitoylethanolamide ga-adịkwa elu na elu. Ya mere, nyocha na mmepe n'ọdịnihu na mmepụta nke Palmitoylethanolamide ga-etinyekwu uche na nchekwa gburugburu ebe obibi, nchekwa na nkwado. N'otu oge ahụ, iji gboo mkpa nke ubi dị iche iche, nchọpụta na mmepe nke ihe ọhụrụ Palmitoylethanolamide ga-aghọkwa ntụziaka dị mkpa n'ọdịnihu.
PEA bụ amide acid fatty endogenous nke sitere na klas nke agonists ihe na-akpata nuklia. E gosipụtara PEA iji jikọta ndị na-anabata ya na nucleus (ndị na-anabata ihe nuklia) ma na-arụ ọrụ dịgasị iche iche nke ndụ ndị metụtara mgbu na-adịghị ala ala. A na-eche na ebumnuche bụ isi bụ peroxisome proliferator-activated receptor alpha (PPAR-alpha).
Suzhou Myland Pharm & Nutrition Inc. bụ onye na-emepụta aha FDA nke na-enye ntụ ntụ Oleoylethanolamide (OEA) dị elu na ịdị ọcha.
Na Suzhou Myland Pharm anyị na-agba mbọ ịnye ngwaahịa kachasị mma na ọnụ ahịa kacha mma. A na-anwale ntụ ntụ Oleoylethanolamide (OEA) nke ọma maka ịdị ọcha na ike, na-eme ka ị nweta mgbakwunye dị elu ị nwere ike ịtụkwasị obi. Ma ịchọrọ ịkwado ahụike cellular, kwalite usoro ahụ ji alụso ọrịa ọgụ ma ọ bụ kwalite ahụike zuru oke, ntụ ntụ Oleoylethanolamide (OEA) bụ nhọrọ zuru oke.
Site na ahụmịhe afọ 30 na teknụzụ dị elu na atụmatụ R&D kachasị mma, Suzhou Myland Pharm ewepụtala ngwaahịa dị iche iche nke asọmpi wee bụrụ mgbakwunye sayensị ndụ ọhụrụ, njikọta omenala na ụlọ ọrụ nrụpụta.
Na mgbakwunye, Suzhou Myland Pharm bụkwa onye nrụpụta FDA debanyere aha. Akụrụngwa R&D nke ụlọ ọrụ ahụ, akụrụngwa nrụpụta na ngwa nyocha bụ nke ọgbara ọhụrụ yana ọtụtụ ọrụ, ma nwee ike imepụta kemịkalụ site na milligrams ruo tọn n'ọ̀tụ̀tụ̀, ma na-agbaso ụkpụrụ ISO 9001 na nkọwapụta GMP.
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Oge nzipu: Sep-27-2024
