Taurine bụ ihe dị mkpa maka obere ihe oriri ma nwee ọtụtụ aminosulfonic acid. A na-ekesa ya nke ọma n'ime anụ ahụ na akụkụ ahụ dị iche iche. Ọ na-adịkarị n'ọnọdụ efu n'ime mmiri interstitial na mmiri intracellular. N'ihi na ọ dị na mbụ na Named mgbe achọtara ya na bile ehi. A na-etinye Taurine na ihe ọṅụṅụ ndị a na-ejikarị eme ihe iji mejupụta ike ma melite ike ọgwụgwụ.
N'oge na-adịbeghị anya, e bipụtala nnyocha gbasara taurine n'akwụkwọ akụkọ atọ kachasị elu bụ Science, Cell, na Nature. Ọmụmụ ihe ndị a ekpughela ọrụ ọhụrụ nke taurine - mgbochi ịka nká, imeziwanye mmetụta nke ọgwụgwọ kansa, na mgbochi oke ibu.
Na June 2023, ndị nchọpụta sitere na National Institute of Immunology na India, Mahadum Columbia dị na United States, na ụlọ ọrụ ndị ọzọ bipụtara akwụkwọ na akwụkwọ agụmakwụkwọ mba ụwa kachasị elu bụ Science. Ọmụmụ ihe ahụ na-egosi na enweghị taurine bụ ihe na-akpata ịka nká. Ịgbakwunye taurine nwere ike ibelata ịka nká nke nematodes, òké, na enwe, ma nwee ike ịgbatị ndụ ahụike nke òké ndị dị afọ etiti site na 12%. Nkọwa: Sayensị: Ike karịrị echiche gị! Taurine nwekwara ike ịgbanwe ịka nká ma gbasaa ndụ?
N'ọnwa Eprel afọ 2024, Prọfesọ Zhao Xiaodi, Prọfesọ Lu Yuanyuan, Prọfesọ Nie Yongzhan, na Prọfesọ Wang Xin si n'ụlọ ọgwụ Xijing nke Mahadum Ọgwụ Ndị Agha nke Anọ bipụtara akwụkwọ n'akwụkwọ akụkọ agụmakwụkwọ mba ụwa kachasị elu bụ Cell. Nnyocha a chọpụtara na mkpụrụ ndụ kansa na-asọmpi mkpụrụ ndụ CD8+ T maka taurine site n'itinye oke ibufe taurine SLC6A6, nke na-akpata ọnwụ na ike ọgwụgwụ mkpụrụ ndụ T, na-eduga na mgbapụ nke mkpụrụ ndụ tumor ahụ, si otú a na-akwalite ọganihu na nlọghachi nke etuto ahụ, ebe ịgbakwunye Taurine nwere ike ime ka mkpụrụ ndụ CD8+ T ndị dara mbà rụọ ọrụ ma melite irè ọgwụgwọ kansa.
Na Ọgọst 7, 2024, ndị otu Jonathan Z. Long nke Mahadum Stanford (Dr. Wei Wei bụ onye edemede mbụ) bipụtara akwụkwọ nyocha akpọrọ: PTER bụ N-acetyl taurine hydrolase nke na-achịkwa nri na oke ibu n'akwụkwọ akụkọ agụmakwụkwọ mba ụwa kachasị elu Nature.
Nnyocha a chọpụtara N-acetyl taurine hydrolase mbụ n'ime anụmanụ ara, PTER, ma kwado ọrụ dị mkpa nke N-acetyl taurine n'ibelata oriri na mgbochi oke ibu. N'ọdịnihu, ọ ga-ekwe omume ịmepụta ihe mgbochi PTER siri ike ma họrọ maka ọgwụgwọ oke ibu.
A na-ahụ Taurine nke ọma n'anụ ahụ anụmanụ na ọtụtụ nri, a na-ahụkwa ya n'ọtụtụ ihe dị ukwuu n'ime anụ ahụ ndị na-akpali akpali dịka obi, anya, ụbụrụ, na akwara. A kọwawo Taurine na ọ nwere ọrụ pleiotropic cellular na physiological, karịsịa n'ihe gbasara metabolism homeostasis. Mbelata mkpụrụ ndụ ihe nketa na ọkwa taurine na-eduga na atrophy akwara, mbelata ikike mmega ahụ, na nsogbu mitochondrial na ọtụtụ anụ ahụ. Mmeju Taurine na-ebelata nrụgide mitochondrial redox, na-eme ka ikike mmega ahụ ka mma, ma na-egbochi ibu ahụ.
Biochemistry na enzymology nke metabolism taurine adọtawo mmasị dị ukwuu na nyocha. N'ụzọ endogenous taurine biosynthetic, a na-eme ka cysteine dioxygenase (CDO) na cysteine sulfinate decarboxylase (CSAD) na-emepụta cysteine iji mepụta hypotaurine, nke na-emesịa Oxidation site na flavin monooxygenase 1 (FMO1) na-emepụta taurine. Na mgbakwunye, cysteine nwere ike imepụta hypotaurine site na ụzọ ọzọ nke cysteamine na cysteamine dioxygenase (ADO). N'okpuru taurine n'onwe ya bụ ọtụtụ metabolites taurine nke abụọ, gụnyere taurocholate, tauramidine, na N-acetyl taurine. Naanị enzyme a maara iji mee ka ụzọ ndị a dị n'okpuru bụ BAAT, nke na-ejikọta taurine na bile acyl-CoA iji mepụta taurocholate na nnu bile ndị ọzọ. Na mgbakwunye na BAAT, achọpụtabeghị njirimara molekul nke enzymes ndị ọzọ na-eme ka metabolism taurine nke abụọ dị n'etiti.
N-acetyltaurine (N-acetyl taurine) bụ ihe na-adọrọ mmasị karịsịa mana a naghị amụ nke ọma nke ọma. Ọkwa N-acetyl taurine na mmiri mmiri ndị dị ndụ na-achịkwa nke ọma site na ọtụtụ nsogbu anụ ahụ nke na-eme ka taurine na/ma ọ bụ acetate flux dịkwuo elu, gụnyere mmega ahụ ntachi obi, ịṅụ mmanya na-aba n'anya, na mgbakwunye taurine na-edozi ahụ. Na mgbakwunye, N-acetyltaurine nwere ihe yiri kemịkalụ na molekul mgbaàmà gụnyere acetylcholine neurotransmitter na acyltaurine N-fatty acyltaurine ogologo nke na-achịkwa shuga ọbara, na-atụ aro na ọ nwekwara ike ịrụ ọrụ dị ka ihe mgbaàmà. Ngwaahịa ahụ na-arụ ọrụ. Agbanyeghị, biosynthesis, mmebi, na ọrụ nwere ike nke N-acetyl taurine ka edoghị anya.
N'ọmụmụ ihe ọhụrụ a, ndị otu nyocha ahụ chọpụtara PTER, enzyme nwa mgbei nke na-enweghị ọrụ a na-amaghị, dị ka nnukwu N-acetyl taurine hydrolase nke anụmanụ na-azụ anụ. N'ime vitro, PTER recombinant gosipụtara oke substrate dị warara na oke mgbochi dị ukwuu. Na N-acetyl taurine, a na-agbanwe ya ka ọ bụrụ taurine na acetate.
Ịchụpụ mkpụrụ ndụ ihe nketa Pter n'ime òké na-eme ka ọrụ hydrolytic nke N-acetyl taurine ghara ịdị irè kpamkpam n'anụ ahụ yana mmụba nke ọdịnaya N-acetyl taurine n'ime anụ ahụ dị iche iche.
Ebe PTER mmadụ dị na-ejikọta ya na body mass index (BMI). Ndị otu nnyocha ahụ chọpụtakwara na mgbe mkpali ya na mmụba nke ọkwa taurine, òké Pter knockout gosipụtara mbelata oriri nri ma na-eguzogide oke ibu nke nri kpatara. ma melite homeostasis glucose. Mgbakwunye nke N-acetyl taurine nye òké ndị buru ibu nke ụdị anụ ọhịa belatakwara oriri na ibu ahụ n'ụzọ dabere na GFRAL.
Data ndị a na-etinye PTER na isi enzyme node nke taurine secondary metabolism ma na-ekpughe ọrụ nke PTER na N-acetyl taurine na njikwa ibu na nguzozi ike.
N'ozuzu, nnyocha a chọpụtara acetyl taurine hydrolase mbụ n'ime anụmanụ ara, PTER, ma kwado ọrụ dị mkpa nke acetyl taurine n'ibelata oriri na mgbochi oke ibu. N'ọdịnihu, a na-atụ anya na a ga-emepụta ihe mgbochi PTER siri ike ma họrọ maka ọgwụgwọ oke ibu.
Nkwupụta: Edemede a bụ maka ozi izugbe naanị, ekwesighikwa ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla. Ụfọdụ ozi sitere na blọgụ sitere na ịntanetị, ọ bụghịkwa ọkachamara. Weebụsaịtị a bụ naanị ọrụ maka nhazi, nhazi na idezi akụkọ. Ebumnuche nke izipu ozi ndị ọzọ apụtaghị na ị kwenyere na echiche ya ma ọ bụ kwado eziokwu nke ọdịnaya ya. Gakwuru ọkachamara ahụike mgbe niile tupu i jiri ihe mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge ozi: Ọgọst-12-2024
