Taurine bụ ihe dị mkpa micronutrient na aminosulfonic acid bara ụba. A na-ekesa ya n'ọtụtụ ebe na anụ ahụ na akụkụ ahụ dị iche iche. Ọ kachasị dị na steeti efu na mmiri interstitial na mmiri intracellular. N'ihi na ọ dị na mbụ n'aha aha ya bụ ka a chọtara ya na bile ehi. A na-agbakwunye Taurine na ihe ọṅụṅụ na-arụ ọrụ nke ọma iji mejupụta ume ma melite ike ọgwụgwụ.
N'oge na-adịbeghị anya, e bipụtala nyocha banyere taurine n'akwụkwọ akụkọ atọ kachasị elu Science, Cell, na Nature. Ọmụmụ ihe ndị a ekpughere ọrụ ọhụrụ nke taurine - mgbochi ịka nká, meziwanye mmetụta nke ọgwụgwọ ọrịa cancer, na mgbochi oke ibu.
Na June 2023, ndị nyocha sitere na National Institute of Immunology na India, Mahadum Columbia dị na United States, na ụlọ ọrụ ndị ọzọ bipụtara akwụkwọ na akwụkwọ akụkọ agụmakwụkwọ mba ụwa kacha elu Science. Ọmụmụ ihe na-egosi na ụkọ taurine bụ ihe na-akpata ịka nká. Ịgbakwunye taurine nwere ike belata ịka nká nke nematodes, oke, na enwe, ma nwee ike ịgbatị ndụ ahụike nke ụmụ oke ndị agadi site na 12%. Nkọwa: Sayensị: Ike karịrị echiche gị! Taurine nwekwara ike gbanwee ịka nká ma gbasaa ogologo ndụ?
N'April 2024, Prọfesọ Zhao Xiaodi, Prọfesọ Prọfesọ Lu Yuanyuan, Prọfesọ Nie Yongzhan, na Prọfesọ Wang Xin sitere na ụlọ ọgwụ Xijing nke Mahadum ahụike agha nke anọ bipụtara akwụkwọ n'akwụkwọ akụkọ agụmakwụkwọ mba ụwa kacha elu. Ọmụmụ ihe a chọpụtara na mkpụrụ ndụ tumor na-asọ mpi CD8 + T maka taurine site n'ịfefe onye na-ebugharị taurine SLC6A6, nke na-ebute ọnwụ T cell na ike ọgwụgwụ, na-eduga n'ịgbapụ mgbapụ nke tumor, si otú ahụ na-akwalite ọganihu tumo na nlọghachi azụ, ebe mgbakwunye Taurine nwere ike ịmaliteghachi mkpụrụ ndụ CD8 + T ike gwụrụ. ma melite irè ọgwụgwọ ọrịa kansa.
Na August 7, 2024, otu Jonathan Z. Long nke Mahadum Stanford (Dr. Wei Wei bụ onye edemede mbụ) bipụtara akwụkwọ nyocha nke akpọrọ: PTER bụ N-acetyl taurine hydrolase nke na-achịkwa nri na oke ibu na ụlọ akwụkwọ agụmakwụkwọ kacha elu nke mba ụwa. akwụkwọ akụkọ Nature.
Ọmụmụ ihe a chọpụtara na mbụ N-acetyl taurine hydrolase na mammals, PTER, ma kwadoro ọrụ dị mkpa nke N-acetyl taurine na-ebelata oriri na mgbochi oke ibu. N'ọdịnihu, ọ ga-ekwe omume ịmepụta ndị na-egbochi PTER dị ike na nhọrọ maka ọgwụgwọ oke ibu.
A na-ahụ taurine n'ọtụtụ ebe n'ime anụ ahụ mammalian na ọtụtụ nri, a na-ahụkwa ya na ọnyà dị elu na anụ ahụ dị egwu dị ka obi, anya, ụbụrụ, na mọzụlụ. A kọwawo Taurine ka ọ na-arụ ọrụ cellular pleiotropic na physiological, karịsịa na ọnọdụ nke homeostasis metabolic. Mbelata mkpụrụ ndụ ihe nketa na ọkwa taurine na-eduga na atrophy muscle, mbelata ikike mmega ahụ, na arụrụ ọrụ mitochondrial n'ọtụtụ anụ ahụ. Mgbakwunye taurine na-ebelata nrụgide mitochondrial redox, na-eme ka mmega ahụ dịkwuo mma, na-ebelata ibu ahụ.
Biochemistry na enzymology nke taurine metabolism adọtala mmasị nyocha dị ukwuu. N'ime ụzọ endogenous taurine biosynthetic ụzọ, cysteine metara site na cysteine dioxygenase (CDO) na cysteine sulfinate decarboxylase (CSAD) iji mepụta hypotaurine, nke mechara Oxidation site na flavin monooxygenase 1 (FMO1) na-emepụta taurine. Na mgbakwunye, cysteine nwere ike ịmepụta hypotaurine site na ụzọ ọzọ nke cysteamine na cysteamine dioxygenase (ADO). N'okpuru taurine n'onwe ya bụ ọtụtụ metabolites taurine nke abụọ, gụnyere taurocholate, tauramidine, na N-acetyl taurine. Naanị enzyme a maara na-eme ka ụzọ ndị a dị ala bụ BAAT, nke na-ejikọta taurine na bile acyl-CoA iji mepụta taurocholate na nnu bile ndị ọzọ. Na mgbakwunye na BAAT, achọpụtabeghị njirimara molikula nke enzymes ndị ọzọ na-eme ka metabolism taurine nke abụọ na-emekọrịta ihe.
N-acetyltaurine (N-acetyl taurine) bụ ihe na-atọ ụtọ nke ukwuu mana metabolite nke abụọ nke taurine amụchaghị nke ọma. A na-achịkwa ọkwa N-acetyl taurine n'ime mmiri mmiri dị ndụ site n'ọtụtụ mgbagwoju anya physiological nke na-abawanye taurine na/ma ọ bụ acetate flux, gụnyere mmega ahụ ntachi obi, ịṅụ mmanya na-aba n'anya, na nri taurine. Na mgbakwunye, N-acetyltaurine nwere myirịta nrụzi kemịkal na ụmụ irighiri ihe ngosi gụnyere neurotransmitter acetylcholine na ogologo agbụ N-abụba acyltaurine nke na-achịkwa shuga ọbara, na-atụ aro na ọ nwekwara ike ịrụ ọrụ dị ka metabolite mgbama ngwaahịa ahụ na-arụ ọrụ. Agbanyeghị, biosynthesis, mbibi, na ọrụ nwere ike ime nke N-acetyl taurine ka edobeghị anya.
N'ime ọmụmụ ihe ọhụrụ a, ndị otu nyocha chọpụtara PTER, enzyme nwa mgbei nke ọrụ amabeghị, dị ka isi mammalian N-acetyl taurine hydrolase. Na vitro, PTER recombinant gosipụtara oke mkpụrụ dị warara yana oke oke. Na N-acetyl taurine, a na-agbanye ya na taurine na acetate.
Ịchụpụ mkpụrụ ndụ Pter na ụmụ oke na-ebute mfu zuru oke nke ọrụ N-acetyl taurine hydrolytic na anụ ahụ yana mmụba n'usoro nke ọdịnaya N-acetyl taurine na anụ ahụ dị iche iche.
A na-ejikọta mpaghara PTER mmadụ na nchịkọta anụ ahụ (BMI). Ndị otu nyocha ahụ gara n'ihu chọpụta na mgbe mkpali na ọkwa taurine na-abawanye, ụmụ oke Pter knockout gosipụtara mbelata oriri nri ma na-eguzogide oke ibu nri kpatara. na mmata glucose homeostasis. Mgbakwunye N-acetyl taurine na ụdị oke ọhịa buru ibu belatara oriri na ịdị arọ ahụ n'ụzọ dabere na GFRAL.
Ihe data ndị a na-etinye PTER na isi enzyme node nke taurine secondary metabolism ma na-ekpughe ọrụ PTER na N-acetyl taurine na njikwa ibu na nguzozi ike.
N'ozuzu, nchọpụta a chọpụtara na mbụ acetyl taurine hydrolase na mammals, PTER, ma kwadoro ọrụ dị mkpa nke acetyl taurine na ibelata oriri na mgbochi oke ibu. N'ọdịnihu, a na-atụ anya na a ga-emepụta ihe mgbochi PTER dị ike na nhọrọ maka ọgwụgwọ oke ibu.
Disclaimer: Edemede a bụ naanị maka ozi izugbe na e kwesịghị ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla. Ụfọdụ ozi biputere blọọgụ na-abịa site na ịntanetị na ọ bụghị ọkachamara. Webụsaịtị a na-ahụ maka nhazi, nhazi na idezi akụkọ. Ebumnuche nke ibuga ozi ndị ọzọ apụtaghị na ị kwenyere n'echiche ya ma ọ bụ kwado na ọdịnaya ya bụ eziokwu. Gakwuru onye ọkachamara ahụike mgbe niile tupu i jiri mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge nzipu: Ọgọst-12-2024
