Ịka nká bụ usoro anụ ahụ ọ bụla na-aga. Ndị mmadụ n'otu n'otu enweghị ike igbochi ịka nká, mana ha nwere ike ịme ihe ụfọdụ iji belata usoro ịka nká na ihe omume nke ọrịa ndị metụtara afọ. Otu ogige enwetala ọtụtụ nlebara anya-nicotinamide riboside, nke a makwaara dị ka NR. Dị ka NAD + precursor, a na-eche na nicotinamide riboside nwere mmetụta mgbochi ịka nká dị egwu. Site n'ịbawanye ọkwa NAD +, nicotinamide riboside na-eme ka ọrụ sirtuin dịkwuo mma, na-eme ka ọrụ mitochondrial dịkwuo mma, na-arụ ọrụ dị iche iche cellular ụzọ na-etinye aka na usoro mgbochi ịka nká.
Nicotinamide riboside (NR) bụ ụdị vitamin B3, nke a makwaara dị ka nicotinic acid ma ọ bụ nicotinic acid. Ọ bụ ihe na-eme n'okike nke a na-ahụ n'obere ntakịrị na nri ụfọdụ, dị ka mmiri ara ehi, yist, na ụfọdụ akwụkwọ nri.
NR bụ ihe mmalite nke nicotinamide adenine dinucleotide (NAD+), coenzyme dị na sel niile dị ndụ. NAD + na-arụ ọrụ dị mkpa n'ọtụtụ usoro ndu, gụnyere mmepụta ume, nrụzi DNA, na nhazi nke metabolism cellular. Ka anyị na-etolite, ọkwa NAD + anyị na-agbada, nke nwere ike imetụta ọrụ ndị a dị oke mkpa. Atụpụtala mgbakwunye NR dị ka ụzọ isi na-abawanye ọkwa NAD + yana ikekwe na-ebelata usoro ịka nká.
Otu n'ime uru kachasị dị na ntinye NR bụ ike ya ịkwalite ọrụ mitochondrial. Mitochondria bụ ụlọ ike nke cell, na-ahụ maka ịmepụta ọtụtụ ume cell n'ụdị adenosine triphosphate (ATP). E gosipụtara NR iji kwalite mmepụta ATP site n'ịbawanye ọkwa NAD +, si otú ahụ na-akwalite mmepụta ume nke ọma na metabolism cellular. Mmụba a na-emepụta ume nwere ike ịbara ụdị anụ ahụ na akụkụ ahụ dị iche iche uru, gụnyere ụbụrụ, obi, na mọzụlụ.
●Mee ka ike cell dịkwuo elu
Nicotinamide riboside na-arụ ọrụ dị mkpa n'ịnye ike n'ụlọ cell, mitochondria. Ngwakọta a bụ ihe mmalite nke nicotinamide adenine dinucleotide (NAD +), coenzyme dị mkpa na-etinye aka na ọtụtụ usoro cellular, ọkachasị metabolism ike. Nnyocha na-egosi na imeju na NR nwere ike ịbawanye ọkwa NAD + ma kwalite iku ume ekwentị na mmepụta ume nke ọma.
Ọkwa NAD + na-agbadata ka anyị na-aka nká, na-eduga n'ọrụ mitochondrial na-adịghị ike ma na-ebelata ọkwa ike zuru ezu. Otú ọ dị, site n'ịgbakwụnye nicotinamide riboside, ọ ga-ekwe omume ịkwụsị ọdịda a ma weghachite ike ntorobịa. A chọpụtakwara NR iji welie ntachi obi anụ ahụ ma melite arụmọrụ egwuregwu, na-eme ka ọ bụrụ ihe na-adọrọ adọrọ maka ndị na-eme egwuregwu na ndị na-achọ ahụike kacha mma.
●Kwalite mmezi cell na mgbochi ịka nká
Akụkụ ọzọ na-adọrọ adọrọ nke nicotinamide riboside bụ ikike ọ nwere ịkwalite nrụzi DNA na igbochi mmebi ndị metụtara afọ. NAD + bụ ihe dị mkpa na usoro nrụzi DNA. Site n'ịgbakwụnye NR iji mụbaa ọkwa NAD +, anyị nwere ike ịkwalite ikike cell imezi DNA, si otú ahụ na-agbachitere nke ọma megide ịka nká.
Na mgbakwunye, NR etinyela aka na nhazi nke isi ụzọ ogologo ndụ, dị ka sirtuins, nke na-arụ ọrụ dị mkpa n'ịkwado ọrụ cellular ahụike. Mkpụrụ ndụ ihe nketa ogologo ndụ ndị a na-enyere aka ịkwalite usoro nchebe cellular megide nrụgide ma kwalite ogologo ndụ ogologo oge. Site na ịgbalite sirtuins, nicotinamide riboside nwere ike inye aka igbu oge ọrịa ndị metụtara afọ ma nwee ike ịgbatị ogologo ahụike anyị.
●Gbochie ọrịa neurodegenerative
Ọrịa Neurodegenerative dị ka Alzheimer na Parkinson na-aghọwanye ihe na-ewu ewu na obodo anyị. Nnyocha na-egosi na nicotinamide riboside nwere ike kwere nkwa igbochi ọrịa ndị a na-agwụ ike. Nnyocha achọpụtala na nchịkwa NR na-eme ka ọrụ mitochondrial dịkwuo elu, na-ebelata nrụgide oxidative, ma na-eme ka neuroplasticity dịkwuo mma, ihe niile na-enye aka na ụbụrụ dị mma.
Na mgbakwunye, ejikọtala mgbakwunye NR na ọrụ ọgụgụ isi na-abawanye, njide ebe nchekwa, yana nkwalite nlebara anya na nlebara anya. Ọ bụ ezie na achọrọ nyocha ọzọ, nchọpụta mmalite ndị a na-egosi na nicotinamide riboside nwere ike ịbụ ihe mgbochi ma ọ bụ nkwado maka ndị mmadụ n'otu n'otu n'ihe ize ndụ nke neurodegeneration.
●Mee ka insulin nwee mmetụta
Ọtụtụ ọmụmụ egosila na NR nwere ike imeziwanye ahụike metabolic n'ozuzu ya. E gosiputara na ọ na-eme ka mmetụta insulin dịkwuo elu, bụ isi ihe na-eme ka ọkwa shuga dị n'ọbara dịkwuo mma yana igbochi mmepe nke ụdị ọrịa shuga 2. Nnyocha achọpụtawokwa na mgbakwunye NR nwere ike melite metabolism lipid, si otú a na-ebelata ọkwa cholesterol na-ekesa na triglyceride. Mmetụta ndị a dị mkpa karịsịa na ndị nwere nsogbu metabolic ma ọ bụ ndị buru ibu ma ọ bụ buru ibu.
●Nwere ikike antioxidant
Na mgbakwunye, egosila NR iji kwalite nchebe cellular megide nrụgide oxidative. Nchegbu oxidative na-eme mgbe enweghị ahaghị nhata n'etiti mmepụta ụdị oxygen na-emeghachi omume (ROS) na ikike ahụ nwere iji antioxidants wepụ ha. Ọnụ ọgụgụ dị elu nke nrụgide oxidative nwere ike imebi mkpụrụ ndụ ma tinye aka na ọganihu nke ọrịa dị iche iche, gụnyere ọrịa cancer, ọrịa obi, na ọrịa neurodegenerative. Nnyocha achọpụtala na mgbakwunye NR nwere ike melite ikike antioxidant nke mkpụrụ ndụ ma belata mmetụta nke nrụgide oxidative na ahụ.
Nnyocha na-egosi na nicotinamide riboside nwere ikike ibelata ịka nká site n'ịbawanye ọkwa nke molekul nicotinamide adenine dinucleotide (NAD+). NAD + bụ molekul bụ isi nke na-arụ ọrụ dị mkpa na metabolism cellular.
Ọkwa NAD+ na-agbadakarị ka anyị na-aka. A na-ewere ọdịda a dị ka isi ihe kpatara usoro ịka nká. Site na ịbawanye ọkwa NAD +, nicotinamide riboside nwere ike inye aka belata ọdịda a wee belata mmetụta nke ịka nká.
NAD + na-etinye aka na ọtụtụ usoro cellular dị mkpa, gụnyere mmepụta ume, nrụzi DNA, na okwu mkpụrụ ndụ ihe nketa. Site na ịbawanye ọkwa NAD +, nicotinamide riboside nwere ike ịkwalite usoro ndị a ma melite ọrụ cellular n'ozuzu ya.
Ọtụtụ nchọpụta egosila nsonaazụ dị mma na sel anụmanụ na mmadụ. N'otu nnyocha, ndị nchọpụta chọpụtara na nicotinamide riboside supplementation mụbara ọkwa NAD + na anụ ahụ anụ ahụ, si otú ahụ na-eme ka ọrụ mitochondrial na mmega ahụ na-arụ ọrụ na ụmụ oke.
Nnyocha ọzọ chọpụtara na mgbakwunye nicotinamide riboside mere ka mmetụta insulin dịkwuo mma na nnabata glucose na oke oke, ndị na-arịa ọrịa shuga. Nke a na-egosi na nicotinamide riboside nwekwara ike ịba uru maka ahụ ike metabolic.
N'ime otu obere ọmụmụ banyere ndị agadi na ndị okenye, nicotinamide riboside supplementation mụbara ọkwa NAD + ma mee ka ọbara mgbali elu na nkwonkwo akwara dịkwuo mma, akara abụọ dị mkpa nke ahụike obi.
N'ọmụmụ ihe ọzọ, ndị nchọpụta chọpụtara na nicotinamide riboside supplementation mere ka uru ahụ dịkwuo mma ma gbochie ọkpụkpụ ahụ na ndị toro eto. Nke a na-egosi na nicotinamide riboside nwere ike ị nweta uru dị iche iche megide mbelata ahụ ike metụtara afọ.
Ọ dị mma ịmara na ịka nká bụ usoro mgbagwoju anya nke ọtụtụ ihe na-emetụta, gụnyere mkpụrụ ndụ ihe nketa, ndụ na gburugburu ebe obibi. Ekwesịrị ileta Nicotinamide riboside dị ka mgbakwunye nke nwere ike inye aka belata ịka nká ma kwado ịka nká kama ịbụ mgbo anwansi.
ỌtụtụNAD+ Achọpụtala ndị na-ebu ụzọ, gụnyere nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), na nicotinic acid (NA). A na-atụgharị ihe mmalite ndị a ka ọ bụrụ NAD + ozugbo n'ime cell.
N'ime ihe mmalite ndị a, nicotinamide riboside anatala nlebara anya zuru oke n'ihi nkwụsi ike ya, bioavailability ya, yana ike ịbawanye ọkwa NAD + nke ọma. NR bụ ụdị vitamin B3 na-apụta n'okike, a na-ahụkwa ya na ọnụọgụ mmiri ara ehi na nri ndị ọzọ. E gosipụtara ya iji kwalite njikọ NAD + ma kpalie ọrụ nke sirtuins, otu protein ndị metụtara ogologo ndụ.
Otu n'ime uru nke nicotinamide riboside bụ ikike ya ịgafe usoro etiti achọrọ maka njikọ NAD +. Enwere ike ịtụgharị ya ozugbo na NAD + na-enweghị mkpa maka enzymes ọzọ. N'ụzọ dị iche, ihe mmalite ndị ọzọ dị ka nicotinamide mononucleotide chọrọ usoro enzymatic ọzọ metụtara nicotinamide phosphoribosyltransferase (NAMPT) ka ọ bụrụ NAD +.
Ọtụtụ ọmụmụ atụnyere ịdị irè nke nicotinamide riboside na ndị ọzọ NAD + precursors, na NR na-apụta mgbe niile. N'ime nyocha izizi na ụmụ oke ịka nká, ahụrụ mgbakwunye nicotinamide riboside iji mee ka ọkwa NAD + dịkwuo elu, melite ọrụ mitochondrial, ma kwalite arụmọrụ akwara.
Nnyocha a na-achịkwaghị achịkwa, kpuru ìsì abụọ, ebe a na-achịkwa placebo na ndị toro eto nwere ahụike gosikwara nsonaazụ na-ekwe nkwa. Ọkwa NAD + mụbara nke ukwuu na ndị sonyere na-ewere nicotinamide riboside ma e jiri ya tụnyere ndị otu placebo. Tụkwasị na nke ahụ, ha kọrọ na ọrụ ọgụgụ isi na-emewanyewanyewanye na ike ọgwụgwụ nke onwe.
Ọ bụ ezie na ndị ọzọ NAD + precursors, dị ka nicotinamide mononucleotide na niacin, egosila mmetụta dị mma na ọkwa NAD + na ụfọdụ ọmụmụ, ha egosibeghị otu ọkwa dị irè dị ka nicotinamide riboside.
Ọ dị mkpa iburu n'obi na ọ bụ ezie na nicotinamide riboside na-egosi na ọ na-arụ ọrụ nke ọma n'ịbawanye ọkwa NAD +, nzaghachi onye ọ bụla nwere ike ịdị iche. Ụfọdụ ndị mmadụ nwere ike ịchọpụta na ihe ndị ọzọ na-ebute ụzọ, dị ka nicotinamide mononucleotide ma ọ bụ niacin, dabara adaba maka mkpa ha.
Ihe mgbakwunye Nicotinamide riboside dị na mbadamba nkume, capsule, na ụdị ntụ ntụ. Ịchọta usoro ọgwụgwọ NR ziri ezi na-adabere n'ụzọ dị ukwuu n'ọtụtụ ihe, gụnyere afọ, ahụike, na mmetụta ndị achọrọ. Ya mere, ọ bụ ihe amamihe dị na ya ịkpọtụrụ onye ọkachamara ahụike tupu ịmalite usoro mgbakwunye ọhụrụ ọ bụla, n'ihi na ha nwere ike ịnye ndụmọdụ ahaziri iche dabere na mkpa gị.
Na mgbakwunye, na njiri mara NR na-arị elu yana ọtụtụ ụdị na-ejupụta n'ahịa, ọ dị oke mkpa ịhọrọ ebe a pụrụ ịdabere na ya na ama ama. Nke a bụ ụfọdụ isi ihe ị ga-atụle mgbe ị na-ahọrọ mgbakwunye NR:
1. Ịdị Ọcha na Ogo: Chọọ ngwaahịa ndị a nwalere na nke ndị ọzọ kwadoro iji hụ na ha na-agbaso ụkpụrụ dị mma. Chọọ ihe mgbakwunye na-enweghị ihe ndochi, ihe mgbakwunye na-emerụ ahụ, na ihe ndị nwere ike imerụ ahụ.
2. Omume Nrụpụta: Họrọ ihe mgbakwunye emepụtara na ụlọ ọrụ FDA-edebanyere aha ma soro ntuziaka Nrụpụta Ọma (GMP). Nke a na-eme ka ngwaahịa ahụ guzosie ike, nchekwa na ịdị irè.
4. Aha na Nyocha Ndị Ahịa: Lelee nyocha ndị ahịa na ọkwa iji nweta nghọta n'ime uru mgbakwunye na afọ ojuju ndị ahịa.
Ajụjụ: Kedu ka Nicotinamide Riboside (NR) si arụ ọrụ?
A: Nicotinamide Riboside (NR) na-arụ ọrụ site na ịbawanye ọkwa nke NAD + n'ime ahụ. NAD + na-etinye aka na mmepụta ike cellular, nrụzi DNA, na idowe ahụike na ọrụ nke mitochondria.
Ajụjụ: Gịnị bụ mmetụta mgbochi ịka nká nke Nicotinamide Riboside (NR)?
A: Nicotinamide Riboside (NR) egosila mmetụta mgbochi ịka nká na-ekwe nkwa site na ọrụ ya n'ịkwalite ọkwa NAD +. Mmụba ọkwa NAD + nwere ike ịkwalite ọrụ mitochondrial, melite mmepụta ume cell, ma kwalite nrụzi DNA, ihe niile nwere ike inye aka n'ịlụso ọdịda metụtara afọ ọgụ na imeziwanye ahụ ike.
Disclaimer: Edemede a bụ naanị maka ozi izugbe na e kwesịghị ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla. Ụfọdụ ozi biputere blọọgụ na-abịa site na ịntanetị na ọ bụghị ọkachamara. Webụsaịtị a na-ahụ maka nhazi, nhazi na idezi akụkọ. Ebumnuche nke ibuga ozi ndị ọzọ apụtaghị na ị kwenyere n'echiche ya ma ọ bụ kwado na ọdịnaya ya bụ eziokwu. Gakwuru onye ọkachamara ahụike mgbe niile tupu i jiri mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge nzipu: Nov-10-2023
