N-Methyl-DL-Aspartic Acid bụ ngwakọta nke klaasị amino asịd. N'ịbụ nke a maara nke ọma maka ọrụ ya na neurobiology, ogige a bụ analog synthetic nke aspartate nke na-eme ka ndị na-anabata N-Methyl-DL-Aspartic Acid na ụbụrụ. Ndị na-anabata NMDA na-arụ ọrụ dị mkpa n'ime usoro sistemụ ụjọ dị iche iche, gụnyere mmụta, ebe nchekwa, na plastik synapti.
Ọ bụrụ na ịchọrọ ịma ihe N-Methyl-DL-Aspartic Acid bụ, ka anyị buru ụzọ ghọta ihe bụ amino acid? Amino acid bụ akụkụ bụ isi nke protein, protein bụ akụkụ bụ isi nke ihe dị iche iche na-arụ ọrụ ndụ na mkpụrụ ndụ mmadụ, dị ka enzymes, ọgwụ mgbochi, mọzụlụ na anụ ahụ. Ịri ezigbo amino acid zuru oke nwere ike ịnọgide na-enwe njikọ na nrụzi protein dị mma, ma kwalite uto na nrụzi nke anụ ahụ.
Amino acid dị mkpa maka ịrụ ọrụ nke ọma nke ọtụtụ sistemu na ọrụ dị n'ime ahụ. Nri ezi uche na nke zuru oke nke amino acid dị iche iche bụ otu n'ime ihe ndị dị mkpa maka ịkwado ahụike.
N-Methyl-DL-Aspartic Acid bụ ihe methylated sitere na aspartic acid (Astentic Acid) nwere otu methyl.
Ọ bụ isomer nke aspartic acid nwere otu methyl jikọtara ya na atom nitrogen. bụ ihe nrụpụta amino acid nke na-arụ ọrụ dị ka onye agonist kpọmkwem na ndị na-anabata NMDA, na-eṅomi omume nke glutamate, neurotransmitter nke na-emekarị na onye nata a.
N-Methyl-DL-Aspartic Acid dị n'ụdị dị iche iche, gụnyere osisi na anụmanụ.
Ọ nwere ụfọdụ ọrụ ndu n'ime ahụ dị ndụ ma na-ekere òkè n'ọtụtụ usoro ọmụmụ physiological, dị ka njikọ na ntọhapụ nke neurotransmitters, protein njikọ, wdg.
Tụkwasị na nke ahụ, ọ bụkwa neuromodulator, N-Methyl-DL-Aspartic Acid nwere mmetụta nchịkwa na usoro ụjọ ahụ, na-ekere òkè na nnyefe mgbaàmà akwara na neuroprotection.
N-Methyl-DL-Aspartic Acid, ihe na-emekarị na ụbụrụ mmadụ, na-arụ ọrụ dị mkpa na synaptic plasticity, usoro dị mkpa na mmụta na nhazi ebe nchekwa. Plastic synapti na-ezo aka n'ikike nke ụbụrụ ụbụrụ synapses iji wusie ike ma ọ bụ daa mbà ka oge na-aga, dabere na ike na ugboro ole ọrụ akwara. NMDAA na-emetụta ndị na-anabata N-Methyl-DL-Aspartic (NMDA), nke na-etinye aka na ike ogologo oge (LTP) - ike nke njikọ synaptik.
Otu ụzọ bụ isi N-Methyl-DL-Aspartic Acid nwere ike isi meziwanye ebe nchekwa bụ site n'ịkwado nzikọrịta ozi n'etiti mkpụrụ ndụ ụbụrụ. NMDA na-arụ ọrụ dị ka neurotransmitter nke na-ejikọta ụfọdụ ndị na-anabata ya na ụbụrụ, karịsịa na hippocampus, bụ nke na-ahụ maka ịmepụta ncheta ọhụrụ. Site na ijikọ ndị nnata ndị a, NMDA na-enyere aka mee ka njikọ dị n'etiti neurons sie ike, na-eme ka ọ dịkwuo mfe maka ịhazi ozi na ịchekwa nke ọma.
Ọzọkwa, ọmụmụ egosila na N-Methyl-DL-Aspartic Acid na-akwalite mwepụta nke ụbụrụ na-enweta neurotrophic factor (BDNF), protein dị mkpa maka uto na nlanarị nke neurons ọhụrụ na ụbụrụ. BDNF na-arụ ọrụ dị mkpa na neuroplasticity, ikike ụbụrụ imegharị na ịhazigharị njikọ akwara na nzaghachi na mmụta na ahụmahụ. Site n'ịbawanye nnweta BDNF, NMDA na-akwado ịmepụta ụzọ akwara ọhụrụ, na-eme ka ma ebe nchekwa na ikike mmụta.
N'ezie, uru nke N-Methyl-DL-Aspartic Acid abụghị nanị na ebe nchekwa na ikike mmụta. Ụfọdụ ọmụmụ na-egosi na ọ nwekwara ike imeziwanye arụmọrụ ọgụgụ isi n'ozuzu ya. E gosipụtara NMDAA ka ọ na-emetụta sistemu neurotransmitter ndị ọzọ, dị ka ụzọ dopaminergic na serotonergic, nke na-etinye aka na nhazi ọnọdụ, nlebara anya, na mkpali. Site n'ịgbanwe usoro ndị a, N-Methyl-DL-Aspartic Acid nwere ike inye aka melite nlebara anya, ịmụrụ anya, na idoanya nke echiche, na-eme ka arụ ọrụ ọgụgụ isi dịkwuo elu.
N'ozuzu, N-Methyl-DL-Aspartic Acid na-egosi nnukwu ikike iji melite ebe nchekwa na mmụta. Na-eme ka ọrụ ọgụgụ isi dị mkpa maka ịga nke ọma agụmakwụkwọ na ọkachamara site na-emetụta plasticity synapti na usoro neuroprotective. Na mgbakwunye, mmetụta ya na sistemụ neurotransmitter ndị ọzọ nwere ike inye aka melite arụmọrụ ọgụgụ isi. Ọ bụ ezie na a ka chọrọ nyocha ọzọ, mgbakwunye NMDAA na-enye ụzọ na-atọ ụtọ maka ndị na-achọ ịkwalite ikike ọgụgụ isi ha na ịnọgide na-enwe nchekwube echiche ha n'oge ndụ ha niile.
N-Methyl-DL-Aspartic Acid bụ amino acid sitere n'okike nke na-arụ ọrụ dị mkpa n'ime usoro physiological dị iche iche na ahụ. A na-achọta ya na nri ndị nwere protein dị ka anụ, azụ, àkwá, na ngwaahịa mmiri ara ehi. Agbanyeghị, ọ dịkwa site na mgbakwunye. Ọzọ, ka anyị nyochaa myirịta na ọdịiche dị n'etiti ịnweta N-Methyl-DL-Aspartic Acid site na isi nri ma were ya dịka mgbakwunye!
Nke mbụ, maka inweta N-Methyl-DL-Aspartic Acid ozugbo site na nri, nri nwere protein nwere amino acid dị iche iche. Ndị mmadụ n'otu n'otu nwere ike gboo mkpa NMDAA ha site na iri nri ziri ezi nke gụnyere isi mmalite protein. Na mgbakwunye, ịnweta N-Methyl-DL-Aspartic Acid site na nri zuru oke nwere uru agbakwunyere nke ịnwe nri ndị ọzọ dị mkpa ị chọrọ maka ahụike zuru oke.
N'aka nke ọzọ, naanị nri nwere ike ọ gaghị ezuru mgbe niile iji gboo mkpa N-Methyl-DL-Aspartic Acid nke ụfọdụ ndị mmadụ. Ndị na-eme egwuregwu, ndị na-ewu ahụ, ma ọ bụ ndị na-enweta ọzụzụ anụ ahụ siri ike nwere ike ịchọ ọkwa dị elu nke NMDAA iji kwado mgbake na uto ahụ ike. N'okwu a, enwere ike ịtụle mgbakwunye N-Methyl-DL-Aspartic Acid.
Ihe mgbakwunye N-Methyl-DL-Aspartic Acid na-abịa n'ụdị dị iche iche, gụnyere ntụ ntụ na capsules, ma dị ngwa ngwa. Ha na-enwekarị NMDAA dị ọcha ma ọ bụ sịntetik, na-eme ka ọ dị mfe ijikwa ma tụọ oriri. Na mgbakwunye, mgbakwunye na-enye ụzọ dabara adaba iji hụ na enwetara N-Methyl-DL-Aspartic Acid zuru oke, ọkachasị maka ndị nwere mgbochi nri, allergies, ma ọ bụ ihe isi ike iri nri nwere protein zuru oke.
Agbanyeghị, ọ dị mkpa ịmara na mgbakwunye N-Methyl-DL-Aspartic Acid kwesịrị iji nlezianya mee ihe. Tupu itinye mgbakwunye ọhụrụ ọ bụla na usoro gị, a na-atụ aro ka ịkpọtụrụ onye ọkachamara ahụike ma ọ bụ onye na-eri nri edebanyere aha. Ha nwere ike nyochaa mkpa gị kpọmkwem wee chọpụta dose N-Methyl-DL-Aspartic Acid kwesịrị ekwesị maka ọnọdụ gị kpọmkwem.
Ọ bụ ezie na mgbakwunye nwere ike inye mgbakwunye ezubere iche ma dịkwa mma, ha ekwesịghị dochie nri zuru oke. Nri zuru oke na-enye ọ bụghị naanị N-Methyl-DL-Aspartic Acid, kamakwa ọtụtụ uru oriri na-edozi ahụ na ahụike. Ịnọgide na-enwe nri kwesịrị ekwesị na ụdị dịgasị iche iche dị mkpa iji hụ na ahụike na ịdị mma dị mma.
N'ịchịkọta, anyị nwere ike nweta N-Methyl-DL-Aspartic Acid site na isi mmalite nri ma ọ bụ site na mgbakwunye. Ọ bụ ezie na nri kwesịrị ekwesị kwesịrị ịbụ isi iyi nke NMDAA, mgbakwunye nwere ike inye ngwọta dị mma maka ndị nwere mkpa kpọmkwem ma ọ bụ ihe mgbochi nri. Agbanyeghị, ọ dị oke mkpa ịchọ ndụmọdụ ọkachamara tupu itinye mgbakwunye ọhụrụ ọ bụla na usoro gị. N'ikpeazụ, ngwakọta nke nri ahụike na mgbakwunye ezubere iche (ọ bụrụ na ọ dị mkpa) nwere ike inye aka hụ na ọkwa kachasị mma nke N-Methyl-DL-Aspartic Acid maka ahụike kacha mma.
Tupu iji NMA, anyị ga-aghọta nchekwa na mmetụta dị n'akụkụ nke NMA, ka anyị wee nwee ike ịrụ ọrụ kachasị elu nke NMA na-emerụghị ahụ.
N'ihe gbasara nchekwa nke mbụ, ọ dị mkpa iburu n'obi na a na-ewerekarị NMA dị mma mgbe ejiri ya na doses kwesịrị ekwesị. Otú ọ dị, dị ka ihe ọ bụla ọzọ, ịṅụbiga mmanya ókè nke NMDA nwere ike ịkpata mmetụta ọjọọ. Ọ dị mkpa ịgbaso ntuziaka akwadoro ma kpọtụrụ ọkachamara ahụike tupu ịmalite mgbakwunye ọ bụla.
Otu n'ime mmetụta ndị NMA nwere ike ime bụ excitotoxicity. Excitotoxicity na-eme mgbe ndị na-anabata NMA na-emebiga ihe ókè, na-eduga na oke calcium ion na mmebi nke neurons na-esote. Ejikọtala ọnọdụ a na ọtụtụ ọrịa neurodegenerative, dị ka Alzheimer na Parkinson. Otú ọ dị, ọ dị mma ịmara na excitotoxicity na-ejikọta ya na nnukwu doses nke NMA, nke a na-adịghị ahụkarị na isi nri nri ma ọ bụ ihe mgbakwunye ọkọlọtọ.
Mmetụta ọzọ dị n'akụkụ NMA bụ mmetụta ọ nwere na nguzozi nke hormonal. Ụfọdụ nnyocha na-egosi na ịṅụbiga mmanya ókè NMA nwere ike igbochi mmepụta na nhazi nke ụfọdụ homonụ, dị ka testosterone. Mgbanwe nke hormonal ndị a nwere ike inwe mmetụta ọjọọ na ahụike ọmụmụ na ọdịmma zuru oke. Otú ọ dị, a chọkwuru nyocha iji ghọta usoro ziri ezi na mmetụta ogologo oge nke NMA na ọkwa hormone.
Na mgbakwunye, ndị nwere ọnọdụ ahụike adịla mbụ kwesịrị ịkpachara anya mgbe ha na-atụle mgbakwunye NMA. Dịka ọmụmaatụ, ndị nwere ọrịa akwụkwụ ma ọ bụ akụkọ ihe mere eme nke epilepsy kwesịrị izere ntinye NMA, n'ihi na ọ nwere ike ịkpalite ọdịdọ n'ihi mmetụta ya na ndị na-anabata NMA.
Maka ojiji echegharịrị, Ọ bụ ezie na a na-echekarị na ọ dị mma mgbe ejiri ya na usoro kwesịrị ekwesị, oke oriri nwere ike ịkpata mmetụta ọjọọ dị ka excitotoxicity na ndakpọ nke homonụ. Ndị nwere ọnọdụ ahụike dịbu adị (karịsịa akwụkwụ na akụkọ ihe mere eme nke akwụkwụ) kwesịrị ịkpachara anya mgbe ị na-atụle mgbakwunye NMA. Dị ka ọ dị na mgbakwunye ọ bụla, ọ dị mkpa ịkpọtụrụ onye ọkachamara ahụike tupu itinye NMA n'ime usoro ọgwụgwọ onye ọ bụla.
Ajụjụ: Ogologo oge ole ka ọ na-eweN-Methyl-DL-Asparticịrụ ọrụ?
A: Mmetụta nke N-Methyl-DL-Aspartic acid nwere ike ịdịgasị iche dabere na onye ọ bụla, usoro onunu ogwu, na usoro nchịkwa. Agbanyeghị, a na-ekwenyekarị na N-Methyl-DL-Aspartic acid nwere ike were ebe ọ bụla site na nkeji ole na ole ruo awa ole na ole ịmalite ịrụ ọrụ. A na-atụ aro ka gị na onye ọkachamara ahụike kpọtụrụ ọkachamara ahụike ma ọ bụ soro ntuziaka ndị nrụpụta nyere maka ozi ndị ọzọ akọwapụtara maka ogologo oge ọ na-ewe maka ogige a ka ọ rụọ ọrụ.
Disclaimer: Edemede a bụ maka ebumnuche ozi naanị na e kwesịghị ịtụle ndụmọdụ ahụike. Gakwuru onye ọkachamara ahụike mgbe niile tupu i jiri mgbakwunye ọ bụla ma ọ bụ gbanwee usoro nlekọta ahụike gị.
Oge nzipu: Jul-07-2023
