Kedu ka Glycerylphosphocholine ga-esi bulie ike ụbụrụ gị?

Glycerylphosphocholine (GPC, nke a makwaara dị ka L-alpha-glycerylphosphocholine ma ọ bụ alphacholine)bụ ihe sitere n'okike nke choline dị n'ụdị nri dị iche iche (gụnyere mmiri ara ara) yana n'ime sel mmadụ niile nwere obere choline. GPC bụ molekul soluble mmiri nke egosiri na ọ bụ isi iyi nke choline ụlọ ọgwụ karịa choline ma ọ bụ phosphatidylcholine (PC) site na nri ma ọ bụ mgbakwunye.

GPC nke a na-eji ọnụ na-etinye ya nke ọma ma na-agbaji ya n'ime enterocytes n'ime glycerol-1-phosphate na choline. Mgbe ị nwetasịrị GPC, ọkwa choline na plasma bilitere ngwa ngwa ma nọgide na-adị elu ruo awa 10. Mmụba mkpokọta plasma dị elu nke choline na-akpali njem ya nke ọma gafee mgbochi ụbụrụ ọbara. Nke a na-abawanye ụlọ ahịa choline n'ime neurons, ebe a na-eji ya emepụta PC na acetylcholine.

N'usoro, α-GPC bụ ngwakọta choline jikọtara ya na molekul glycerol site na otu phosphate, yana choline nwere phospholipid. Ọdịnaya nke choline dị oke elu, na-aza ihe dịka 40%, nke pụtara na 1000 mg nke α-GPC nwere ike imepụta ihe dịka 400 mg nke choline n'efu.

Choline bụ nri dị mkpa dị na ngwaahịa mmiri ara ehi na akwa na-enyere mkpụrụ ndụ aka ịnọgide na-enwe akpụkpọ ahụ ha. Choline n'onwe ya dịkwa mkpa iji mee acetylcholine. Ọ bụ ezie na alpha-GPC na ndị ọzọ choline dị ka phosphatidylcholine na lecithin nwere ike ịkwalite mmepụta nke acetylcholine, alpha-GPC dị elu n'ezie n'ihi na lipids ọ na-enye na-eme ka ọ dịkwuo mfe maka mkpụrụ ndụ ịmịkọrọ, ihe karịrị 90% nke phosphatidylcholine na-etinye uche na arịa lymphatic. , ebe α-GPC na-etinyekarị ya site na vein portal, ya mere ntinye ntinye aka dị elu, si otú a na-akwalite mmepụta nke acetylcholine nke ọma. Acetylcholine bụ neurotransmitter nke na-arụ ọrụ dị mkpa n'ịhazi ọrụ ụbụrụ na njikwa akwara. Ọ bụ ezie na anyị nwere ike iri choline site na nri, ọnụ ọgụgụ nke acetylcholine na-ebelata ka afọ.

Uru nke GPC dabere na nyocha

Ọrụ ụbụrụ

• Na-eme ka ebe nchekwa dịkwuo mma, itinye uche na oge mmeghachi omume na ndị okenye na ndị na-eto eto
• Na-akwalite mmepụta na ntọhapụ nke acetylcholine (ACh) site na neurons na ikekwe sel ndị ọzọ.
• Nwere ike kwụọ ụgwọ maka mbelata nke ACh kpatara site na ịka nká, ụkọ estrogen (menopause, na ikekwe ọgwụ mgbochi ọnụ)
• Melite ụkpụrụ EEG
• Na-abawanye mmepụta nke dopamine, serotonin na GABA18.
• melite ọrụ mitochondrial n'oge ischemia / nrụgide oxidative
• na-egbochi mbelata metụtara afọ na mkpụrụ ndụ ụbụrụ yana ọnụọgụ nnabata ACh, ọrụ akwara na mmepụta homonụ uto
• Kwalite mmepụta homonụ nke uto na ndị na-eto eto na ndị okenye
• Na-abawanye oxidation abụba, ike akwara na oge mmeghachi omume, ikekwe na-emezi nguzozi, karịsịa na ndị okenye.

Ndozi ụbụrụ na nkwado Alzheimer/Dementia

• Na-eme ka ụbụrụ gbakee mgbe ọrịa strok gasịrị, mmerụ ahụ ụbụrụ na-emerụ ahụ, na anesthesia (tupu na mgbe ịwachara ahụ).
• Dozie anụ ahụ mgbochi ọbara-ụbụrụ mebiri site na ọbara mgbali elu
• Ọ na-eme ka nghọta na omume ọha na eze dịkwuo mma na ọrịa Alzheimer, vaskụla vaskụla / senile dementia, na ọrịa Parkinson.
• Belata mbelata ụbụrụ ụbụrụ dịka ọrịa Alzheimer
• nwere ike ịba uru na ọrịa ndị chọrọ nrụzi myelin na Duchenne muscular dystrophy Choline na-arụ ọrụ na metabolism nke mmadụ na GPC.

Ngwongwo pụrụ iche dị ka isi iyi siri ike nke choline, ngọngọ ụlọ nke acetylcholine na ihe na-eme ka njikọ ya na nzuzo pụta.

• Acetylcholine bụ neurotransmitter na ụbụrụ na transducer mgbaàmà n'ebe ndị ọzọ n'ime ahụ, dị oké mkpa maka muscle mkpụkọ, akpụkpọ ụda, eriri afọ motility, na ndị ọzọ anụ ahụ ọrụ. N'adịghị ka choline / PC nyere site na nri ma ọ bụ mgbakwunye, GPC supplementation gosiri na ọ nwere mmetụta na-akpali akpali na njikọ nke ACh na ntọhapụ ya na sel cholinergic.

Mgbakwunye GPC rụpụtara na nkwalite cholinergic nrịbama na neurons na sel ndị ọzọ nwere ike imepụta acetylcholine. Nke a bara uru karịsịa mgbe ọnụọgụ na ọrụ dị irè nke neurons cholinergic belatara n'ihi ịka nká nkịtị ma ọ bụ usoro mmebi dị iche iche. Mgbakwunye na GPC nwere ikike iji kwụọ ụgwọ maka mmebi ndị a n'ihi na ọ na-ebute mmụba ngwa ngwa na choline plasma, nke na-eme ka mkpụrụ ndụ dị ike na enzymes na ndị na-ebugharị n'ụzọ ndị a.

Ihe owuwu ụlọ nke phosphatidylcholine (PC)

• PC bụ nke phospholipids ma bụrụ akụkụ dị mkpa nke membranes cell na mitochondrial membranes. Ikike nke mgbakwunye GPC iji nyere aka mgbake ọrịa strok, yana igbochi mbelata nke afọ ndị na-anabata ACh na mkpụrụ ndụ akwara ma ọ bụ ụbụrụ, bụ ihe akaebe ọzọ nke ntinye aka na mmezi akpụkpọ anụ neuronal site na njikọ PC.

Nhazi nke sphingomyelin

• Sphingomyelin bụ akụkụ nke n'ọbọ myelin nke na-ekpuchi ma na-egbochi neurons na irighiri akwara. Ya mere, mgbakwunye GPC nwere ike ịba uru n'ọnọdụ ọ bụla na-enwewanye ọchịchọ maka nrụzi myelin, dị ka neuropathy, multiple sclerosis, na ọnọdụ ndị ọzọ metụtara demyelination na autoimmunity nke anụ ahụ ụjọ. Ụgbọ njem nke abụba n'ime na n'èzí sel

• PC dị mkpa maka njikọ na nzuzo nke akụkụ VLDL. Triglycerides na-ahapụ imeju n'ime akụkụ VLDL, nke na-akọwa ihe kpatara ụkọ choline na-abawanye ohere nke ọrịa imeju abụba abụba. Enwere ike nweta PC site na isi mmalite nri ma ọ bụ mgbakwunye; Otú ọ dị, PC maka phospholipids na lipoproteins adịghị enweta ozugbo site na PC etinyere ma ọ bụ nke emebere ya. A na-emepụta ya site na choline precursors dị iche iche (gụnyere GPC), ya mere ingesting PC abụghịchaghị ụzọ kacha dị irè isi bulie ọdọ mmiri PC.
Na-akwado motility spam

• GPC bụ isi ihe na ntinye nke DHA (docosahexaenoic acid), na-eme PC-DHA. A na-eji ihe mgbagwoju DHA-PC mee ihe n'ụdị cell na-arụsi ọrụ ike dị ka sel na-ahụ ìhè retina na sel sperm. DHA-PC na-abawanye mmiri mmiri nke akpụkpọ ahụ, nke dị oke mkpa maka ọrụ sperm dị mma. Semen nwere nnukwu mkpokọta GPC; A na-ewepụta mkpụrụ ndụ epididymal nke na-akọpụta mkpụrụ ndụ sperm site na ọdọ mmiri GPC wee mepụta PC-DHA. Ọkwa dị ala nke GPC na PC-DHA n'ime semen nwere ike ime ka ohere nke mbelata sperm motility.

Ntụle GPC na Acetyl-L-Carnitine (ALCAR)

• N'ime nnyocha nke ndị ọrịa nwere ọrịa Alzheimer dị elu, GPC mere ka ọganihu dị ukwuu na ọtụtụ ihe gbasara neuropsychological tụnyere ALCAR. Ọ bụ ezie na ogige abụọ ahụ na-akwado mmụba nke acetylcholine, a na-eche na enwere ike inwe mmetụta synergistic n'etiti imeju ogige abụọ ahụ, dịka GPC na-enye choline ebe ALCAR na-enye akụkụ acetyl maka njikọ nke acetylcholine.

Enwere ike imekọrịta n'etiti GPC na ọgwụ. A naghị eche na mgbakwunye GPC ga-egbochi ọgwụ ọ bụla emebere iji melite ọrụ ụbụrụ. N'ezie, n'ihi uru ya na ụzọ cholinergic na imeziwanye ọrụ akpụkpọ anụ neuronal, ọ nwere ike ịkwalite uru ha n'ezie. GPC nwere ike ịkwalite mmetụta nke acetylcholinesterase AChE inhibitors n'ihi na ọ nwere ike ịbawanye ọnụ ọgụgụ ACh na mgbawa synapti, ebe ọgwụ ndị a na-ebelata mmebi ya.

Na mgbakwunye, dị ka ọmụmụ anụmanụ si kwuo, GPC nwere ike ịkwalite mmepụta nke dopamine, serotonin, ma ọ bụ GABA na ụbụrụ, na GPC nwere ike ime ka mmetụta nke reuptake inhibitors nke ndị na-eme ihe na-adịghị mma.

Suzhou Myland Pharm & Nutrition Inc. bụ onye na-emepụta aha FDA nke na-enye ntụ ntụ Alpha GPC dị elu na nke dị elu.

Na Suzhou Myland Pharm anyị na-agba mbọ ịnye ngwaahịa kachasị mma na ọnụ ahịa kacha mma. A na-anwale ntụ ntụ Alpha GPC anyị nke ọma maka ịdị ọcha na ike, na-eme ka ị nweta mgbakwunye dị elu ị nwere ike ịtụkwasị obi. Ma ịchọrọ ịkwado ahụike cellular, kwalite usoro ahụ ji alụso ọrịa ọgụ ma ọ bụ kwalite ahụike zuru oke, ntụ ntụ Alpha GPC anyị bụ nhọrọ zuru oke.

Site na ahụmịhe afọ 30 na teknụzụ dị elu na atụmatụ R&D kachasị mma, Suzhou Myland Pharm ewepụtala ngwaahịa dị iche iche nke asọmpi wee bụrụ mgbakwunye sayensị ndụ ọhụrụ, njikọta omenala na ụlọ ọrụ nrụpụta.

Na mgbakwunye, Suzhou Myland Pharm bụkwa onye nrụpụta ndebanye aha FDA. Akụrụngwa R&D nke ụlọ ọrụ ahụ, akụrụngwa nrụpụta na ngwa nyocha bụ nke ọgbara ọhụrụ yana ọtụtụ ọrụ, ma nwee ike imepụta kemịkalụ site na milligrams ruo tọn n'ọ̀tụ̀tụ̀, ma na-agbaso ụkpụrụ ISO 9001 na nkọwapụta GMP.