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Ijikwa ike nke Berberine: mee ka ọdịmma gị dịkwuo mma

Nature na-enye anyị ọtụtụ akụ ma a bịa n'ịkwado ahụike, nke ọ bụla nwere ihe pụrụ iche na uru ya. Otu n'ime ihe ndị dị otú ahụ dị oké ọnụ ahịa zoro ezo bụ berberine, ihe a na-achọta n'ụdị osisi dị iche iche nke a maara maka ihe na-eme ka ahụ ike dị egwu.

Kedu ihe bụ Berberine 

 Berberine bụ alkaloid na-acha odo odo nke na-apụta n'ụdị osisi dị iche iche, gụnyere mgbọrọgwụ, rhizomes, ị ga na ogbugbo. Ụfọdụ isi mmalite berberine na-agụnye ahịhịa dị ka grape Oregon, goldenseal, na skullcap. Omenala ndị China na ọgwụ Ayurvedic ejiriwo ike osisi ndị a gwọọ ọrịa dịgasị iche iche ruo ọtụtụ narị afọ, a na-ewerekwa berberine dị ka isi ihe na-agwọ ọrịa.

Kedu ihe bụ Berberine

Ọ bụkwa ihe na-arụsi ọrụ ike n'ime ọgwụ abụọ a ma ama: coptis na phellodendron.

Berberine nwere uru ahụike dị iche iche. Site n'ịchịkwa ọkwa shuga na cholesterol ruo n'igosipụta antioxidant, antibacterial na mgbochi mkpali, berberine bụ onyinye pụrụ iche nke okike n'ezie. Ma ejiri ya dị ka ọgwụgwọ mgbakwunye ma ọ bụ dị ka ihe mgbochi, ikike berberine dị ukwuu ma nwee ike inye aka mee ka ndụ dịkwuo mma ma dị ike karị.

Uru ahụike Berberine

Ọrụ Berberine n'ịchịkwa ọrịa shuga

Ọrịa shuga bụ ọrịa na-adịghị ala ala nke na-emetụta ọtụtụ nde mmadụ n'ụwa niile. Ihe e ji mara ya bụ shuga dị n'ọbara dị elu n'ihi enweghị mmepụta insulin nke anụ ahụ ma ọ bụ enweghị ike iji insulin rụọ ọrụ nke ọma.

Nguzogide insulin bụ ihe e ji amata ụdị ọrịa shuga 2, nke mmeghachi omume anụ ahụ na mmetụta insulin na-ebelata. Nnyocha achọpụtala na berberine nwere ike ime ka nnabata glucose dị n'ime cell, si otú a na-enyere aka ịhazi ọkwa shuga dị n'ọbara. Ọ na-ebelata mmepụta nke glucose n'ime imeju, na-enye aka n'ihu n'ịkwalite njikwa shuga ọbara.

Ọzọkwa, egosila na berberine na-egbochi mmepụta nke ihe nrịbama ọkụ, na-ebelata mbufụt, ma nwee ike igbochi nsogbu ọrịa shuga dị ka ọrịa obi na akwara na mmebi akụrụ.

Na mgbakwunye na mmetụta ya na mmetụta insulin na mbufụt, berberine egosila ikike ịkwalite profaịlụ lipid. Ọrịa shuga na-abawanye ohere nke dyslipidemia, nke e ji ọkwa cholesterol dị elu na triglyceride mara. Nnyocha achọpụtala na berberine nwere ike belata mkpokọta cholesterol, LDL cholesterol, na ọkwa triglyceride ka ọ na-abawanye cholesterol HDL, si otú ahụ na-enye profaịlụ lipid dị mma karị.

Ọrụ Berberine n'ịchịkwa ọrịa shuga

Nwere ike inye aka kwado ahụike obi

Nnyocha achọpụtala na berberine nwere ihe dị iche iche nwere ike ịkwado ahụike obi. Ọ nwere njikwa shuga ọbara yana mmetụta na-ebelata lipid, nke dị oke mkpa maka ịnọgide na-enwe ahụike obi.

Nnyocha achọpụtala na berberine na-arụ ọrụ enzyme a na-akpọ adenosine monophosphate-activated protein kinase (AMPK), nke na-arụ ọrụ dị egwu na ntinye insulin na glucose metabolism. Site n'ịkwalite mmetụta insulin, berberine nwere ike inye aka ịhazi ọkwa shuga dị n'ọbara ma belata ihe egwu nke ọrịa metabolic, nke nwere ike imetụta ahụike obi na-adịghị mma.

Nnyocha na-egosi na berberine nwere ike imeziwanye ọrụ obi site n'ịkwalite nkwekọrịta akwara obi na ibelata nrụgide oxidative. Site n'ịbawanye ike na arụmọrụ nke mkpụkọ akwara obi, berberine nwere ike inye aka na ahụike sistemu obi niile.

Ka ọ dị ugbu a, ibi ndụ dị mma, gụnyere nri kwesịrị ekwesị, mmega ahụ mgbe niile na nyocha ahụike mgbe niile, ka dị oke mkpa iji nọgide na-enwe ezi obi.

Nwere ike inye aka kwado ahụike obi

Berberine na-akwado ibelata cholesterol

Nnyocha na-egosi na berberine nwere ike ibelata mkpokọta cholesterol, LDL cholesterol, na ọkwa triglyceride n'ụzọ dị irè, ma na-abawanye cholesterol HDL. Mmetụta berberine ndị a na-eweda egbugbere ọnụ nwere ike inye aka mee ka profaịlụ lipid dị mma ma belata ihe ize ndụ nke ọrịa obi.

Berberine na-arụ ọrụ ya na-ebelata cholesterol site na igbochi enzyme a na-akpọ PCSK9. PCSK9 na-arụ ọrụ dị mkpa n'ịhazi ọkwa LDL cholesterol n'ime ọbara. Mgbe PCSK9 na-emebiga ihe ókè, ọ na-eduga n'ọkwa LDL cholesterol dị elu, nke na-eduga n'ịmepụta plaque n'ime akwara na n'ikpeazụ ọrịa obi. E gosiputara Berberine na-egbochi mmepụta PCSK9, si otú a na-ebelata ọkwa LDL cholesterol ma melite ahụike obi. 

Ọzọkwa, a chọpụtala na berberine na-emetụta njikọ nke cholesterol n'ime imeju. Ọ na-egbochi enzyme a na-akpọ HMG-CoA reductase, nke na-ahụ maka mmepụta cholesterol n'ime ahụ. Site na igbochi enzyme a, berberine na-ebelata njikọ cholesterol ma na-eduga n'ọkwa LDL cholesterol dị ala.

Na mgbakwunye na mmetụta ya na cholesterol, berberine nwekwara mmetụta mgbochi mkpali na antioxidant, nke na-enye aka na uru nke obi ya. Amara mbufụt na-adịghị ala ala na nrụgide oxidative bụ ihe ndị dị ize ndụ maka ọrịa obi. Nnyocha achọpụtala na berberine nwere ike igbochi mmepụta nke mkpụrụ ndụ pro-inflammatory ma kwalite ọrụ nke enzymes antioxidant, n'ikpeazụ na-ebelata ihe ize ndụ nke nsogbu obi.

Enwere ike nke Berberine maka mbelata ibu

E gosiputara Berberine na-akwalite metabolism metabolism, si otú a na-enyere aka ịhazi ọkwa shuga dị n'ọbara. Site na imeziwanye mmetụta insulin, berberine na-enyere ahụ aka iji glucose rụọ ọrụ nke ọma ma na-egbochi oke glucose ka ọ bụrụ nchekwa abụba. 

Na mgbakwunye, berberine nwere ikike ịkwalite lipolysis site na ịgbalite enzyme a na-akpọ adenosine monophosphate-activated protein kinase (AMPK). A maara enzyme a dị ka "Mgbanwe nke Metabolic Master Switch" n'ihi na ọ na-arụ ọrụ dị mkpa n'ịhazi metabolism ike na inye aka n'ibelata ibu. Site n'ịgbalite AMPK, berberine nwere ike inye aka kwalite abụba oxidation na igbochi njikọ abụba, na-eduga na ọnwụ.

Achọpụtala Berberine na-emetụta eriri afọ microbiome, nke na-arụ ọrụ dị mkpa na njikwa ibu. Nnyocha na-egosi na berberine nwere ike ịgbanwe nhazi nke microbiota intestinal, na-akwalite uto nke nje bacteria bara uru na igbochi uto nke nje bacteria na-emerụ ahụ. Microbiome gut ziri ezi dị mkpa maka ịnọgide na-enwe ahụ ike n'ihi na ọ na-emetụta mmịpụta ike na nri ma na-achịkwa metabolism.

Otú ọ dị, ọ dị mkpa icheta na ịbelata ibu bụ usoro mgbagwoju anya nke ọtụtụ ihe na-emetụta, gụnyere nri, mgbatị ahụ, na nhọrọ ndụ. Inweta berberine dị ka akụkụ nke usoro njikwa ibu n'ozuzu nwere ike inye nkwado ọzọ n'inweta na ịnọgide na-enwe ahụ ike.

Enwere ike nke Berberine maka mbelata ibu

Njikọ dị n'etiti Berberine na Gut Health

Nnyocha na-egosi na berberine nwere ike inye aka weghachite na ịnọgide na-enwe microbiome eriri afọ dị mma. Nnyocha e bipụtara na akwụkwọ akụkọ Nature Communications chọpụtara na berberine na-abawanye ụdị nje bacteria dị iche iche, na-akwalite uto nke ụdị bara uru dị ka Bifidobacterium na Lactobacillus. A maara nje bacteria ndị a maka mmetụta nchebe ha megide mbufụt na imeziwanye ọrụ mgbochi eriri afọ.

Nnyocha ọzọ e bipụtara n'akwụkwọ akụkọ Frontiers in Microbiology mere ka ọ pụta ìhè njirimara antimicrobial nke berberine. A chọpụtala na ọ na-egbochi uto nke nje bacteria dị iche iche na-emerụ ahụ, gụnyere E. coli na salmonella. Site n'ibelata ọnụ ọgụgụ nke microorganisms pathogenic, berberine nwere ike inye aka mezie microbiome gut ma kwalite usoro nri nri dị mma.

Na mgbakwunye na mmetụta ya kpọmkwem na nje bacteria eriri afọ, a chọpụtala berberine na-achịkwa mmepụta nke enzymes digestive dị iche iche. Enzymes ndị a na-ahụ maka ịkụda nri na ịhụ na absorption kwesịrị ekwesị na-edozi ahụ. Nnyocha na-egosi na berberine nwere ike ịkwalite ọrụ nke ụfọdụ enzymes, dị ka amylase na lipase, si otú ahụ na-eme ka mgbari nri na nri na-edozi ahụ.

Mmeju na usoro onunu ogwu, Mmetụta 

Enwere ike ịgbakwunye Berberine na ndụ mmadụ n'ụdị mgbakwunye nri, nke kachasị na ya bụ berberine hydrochloride.

Ebipụtara usoro onunu ogwu kacha mma:

Ịchọpụta ezigbo usoro ọgwụgwọ berberine nwere ike ịbụ ọrụ siri ike. Ọtụtụ ihe na-arụ ọrụ dị oke mkpa, gụnyere ahụike gị yana nsonaazụ achọrọ. N'ozuzu, a na-atụ aro ka ịmalite site na obere dose ma jiri nwayọọ nwayọọ mụbaa dose ahụ ka oge na-aga. Maka nkwado ahụike izugbe, usoro ọgwụgwọ ọkọlọtọ bụ 500 mg ruo 1500 mg kwa ụbọchị, kewara n'ime ọtụtụ doses. Agbanyeghị, ọ dị mkpa ịgakwuru onye ọkachamara ahụike ma ọ bụ soro ntuziaka akọwapụtara ngwaahịa maka ndụmọdụ usoro onunu n'otu n'otu. 

 Kpachara anya maka mmetụta ndị nwere ike ime:

Ọ bụ ezie na berberine nwere uru ahụike dị mma, ọ dị mkpa ịtụle mmetụta ndị nwere ike ime. Dị ka mgbakwunye ọ bụla, ọ nwere ike ọ gaghị adabara onye ọ bụla. Ụfọdụ ndị mmadụ nwere ike ịnweta ahụ erughị ala afọ dị ka afọ ọsịsa, afọ ntachi, ma ọ bụ mgbu afọ. Na mgbakwunye, berberine nwere ike iji ọgwụ ụfọdụ emekọrịta ihe, gụnyere nke imeju metabolized. Ya mere, ọ dị mkpa ịkpọtụrụ onye ọkachamara ahụike tupu itinye mgbakwunye berberine na ndụ gị kwa ụbọchị.

Ọ bụ ezie na a na-amata ihe mgbakwunye berberine maka uru ahụike ha nwere, ọ dị mkpa icheta na ahụike kachasị mma na-adabere na ihe mgbakwunye. Nri kwesịrị ekwesị, mmega ahụ mgbe niile na ihi ụra zuru oke bụ ihe ndị bụ isi na ahụike zuru oke. Ekwesịrị iwere Berberine dị ka mgbakwunye maka ibi ndụ ahụike karịa ka ọ bụrụ ihe ngwọta naanị ya.

Ajụjụ: berberine nwere ike inye aka na ọnwụ?
A: Ee, ọmụmụ egosila na berberine nwere ike inye aka na ọnwụ dị arọ site n'ịba ụba nke metabolism, ibelata njikọ abụba, na ịkwalite mmebi nke abụba.
Ajụjụ: Ebee ka m nwere ike ịhụ ihe mgbakwunye berberine?
A: Enwere ike ịhụ ihe mgbakwunye Berberine n'ụlọ ahịa nri ahụike dị iche iche, ụlọ ahịa ọgwụ, na ndị na-ere ahịa n'ịntanetị. Chọọ ụdị aha ama ama na-enye ozi doro anya gbasara isi mmalite, ịdị ọcha na ịdịmma ngwaahịa ha.

Disclaimer: Bọọgụ blọgụ a na-eje ozi dị ka ozi izugbe ma ekwesighi ka ewere ya dị ka ndụmọdụ ahụike. Gakwuru onye ọkachamara ahụike mgbe niile tupu i jiri mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.

Oge nzipu: Sep-21-2023